按摩与康复医学
按摩與康複醫學
안마여강복의학
Chinese Manipulation & Rehabilitation Medicine
2015年
1期
82-85,86
,共5页
骆伟雄%赵自明%赵静宇%曾晓会%黄雪君%陈玉兴
駱偉雄%趙自明%趙靜宇%曾曉會%黃雪君%陳玉興
락위웅%조자명%조정우%증효회%황설군%진옥흥
痤疮%痤消饮颗粒%药效学%性激素%抗炎
痤瘡%痤消飲顆粒%藥效學%性激素%抗炎
좌창%좌소음과립%약효학%성격소%항염
acne%acne elminating granule%pharmacodynamics%sex hormone%anti-inflammatory
目的：观察祛风清肺、清热解毒中药痤消饮颗粒（CXY，银花、连翘、牛子、荆芥、薄荷等）治疗痤疮的药理效应。方法：观察CXY高、中、低剂量（2、1、1/2倍临床等效剂量，下同）对①痤疮丙酸杆菌所致耳廓痤疮模型大鼠耳廓肿胀度、病变分级和病理的影响；②雄性去势小鼠血清睾酮及精囊腺、前列腺指数；③雌性去势小鼠血清雌二醇（E2）和子宫指数；④棉球肉芽肿大鼠肉芽肿干、湿重；⑤角叉菜胶所致小鼠足跖肿胀度和足跖肿胀率的影响。结果：与模型组相比，CXY三剂量均可显著降低耳廓痤疮大鼠耳廓肿胀度和病变分级（P<0.01），明显改善大鼠耳廓组织炎性病变；CXY三剂量均可显著减少雄性去势小鼠血清睾酮、精囊腺、前列腺指数（P<0.05、0.01和0.05），增加雌性去势小鼠血清E2、子宫指数（P<0.01），减小大鼠棉球肉芽肿湿重和干重（P<0.01），减少角叉菜胶所致足跖肿胀小鼠足跖肿胀度和肿胀率（P<0.01）。结论：CXY可能通过增加雌性激素同时抑制雄性激素分泌，并发挥抗炎（增殖性和渗出性）效应，从而缩小痤疮病灶大小、改善痤疮病灶炎性病变分级，有确切的抗痤疮作用，适用于寻常痤疮的临床治疗。
目的：觀察祛風清肺、清熱解毒中藥痤消飲顆粒（CXY，銀花、連翹、牛子、荊芥、薄荷等）治療痤瘡的藥理效應。方法：觀察CXY高、中、低劑量（2、1、1/2倍臨床等效劑量，下同）對①痤瘡丙痠桿菌所緻耳廓痤瘡模型大鼠耳廓腫脹度、病變分級和病理的影響；②雄性去勢小鼠血清睪酮及精囊腺、前列腺指數；③雌性去勢小鼠血清雌二醇（E2）和子宮指數；④棉毬肉芽腫大鼠肉芽腫榦、濕重；⑤角扠菜膠所緻小鼠足蹠腫脹度和足蹠腫脹率的影響。結果：與模型組相比，CXY三劑量均可顯著降低耳廓痤瘡大鼠耳廓腫脹度和病變分級（P<0.01），明顯改善大鼠耳廓組織炎性病變；CXY三劑量均可顯著減少雄性去勢小鼠血清睪酮、精囊腺、前列腺指數（P<0.05、0.01和0.05），增加雌性去勢小鼠血清E2、子宮指數（P<0.01），減小大鼠棉毬肉芽腫濕重和榦重（P<0.01），減少角扠菜膠所緻足蹠腫脹小鼠足蹠腫脹度和腫脹率（P<0.01）。結論：CXY可能通過增加雌性激素同時抑製雄性激素分泌，併髮揮抗炎（增殖性和滲齣性）效應，從而縮小痤瘡病竈大小、改善痤瘡病竈炎性病變分級，有確切的抗痤瘡作用，適用于尋常痤瘡的臨床治療。
목적：관찰거풍청폐、청열해독중약좌소음과립（CXY，은화、련교、우자、형개、박하등）치료좌창적약리효응。방법：관찰CXY고、중、저제량（2、1、1/2배림상등효제량，하동）대①좌창병산간균소치이곽좌창모형대서이곽종창도、병변분급화병리적영향；②웅성거세소서혈청고동급정낭선、전렬선지수；③자성거세소서혈청자이순（E2）화자궁지수；④면구육아종대서육아종간、습중；⑤각차채효소치소서족척종창도화족척종창솔적영향。결과：여모형조상비，CXY삼제량균가현저강저이곽좌창대서이곽종창도화병변분급（P<0.01），명현개선대서이곽조직염성병변；CXY삼제량균가현저감소웅성거세소서혈청고동、정낭선、전렬선지수（P<0.05、0.01화0.05），증가자성거세소서혈청E2、자궁지수（P<0.01），감소대서면구육아종습중화간중（P<0.01），감소각차채효소치족척종창소서족척종창도화종창솔（P<0.01）。결론：CXY가능통과증가자성격소동시억제웅성격소분비，병발휘항염（증식성화삼출성）효응，종이축소좌창병조대소、개선좌창병조염성병변분급，유학절적항좌창작용，괄용우심상좌창적림상치료。
Objective:To observe the pharmacological effect of the herbs that expelling wind and clearing lung, heat clearing and detoxicating that named acne elminating granule (CXY, honeysuckle, forsythia suspensa, fructus arctii, schizonepeta, mint, etc) in treatment for acne. Methods:To ob-serve the influence of high, middle and low CXY dose (2, 1 and 1/2 times clinical equivalent dose, the same below) on①the effect on auricle swell-ing degree, pathological grading and pathology of auricle acne on rat models that caused by propionibacterium acnes;②the serum testosterone and seminal vesicle, prostate indexes of castrated male rats;③the serum estradiol (E2) and uterus index of castrated female rats;④the dry and wet weight of granuloma in tampon granuloma rats; ⑤the swelling degree and rate of rats with paw swelling that caused by carrageenin. Results: Compared with model group, the 3 doses of CXY could all significantly reduce the auricle swelling degree and pathological grading (P<0.01), significantly im-prove the inflammatory lesion of rats' auricle tissue;could all significantly decrease the serum testosterone, seminal vesicle and prostate indexes of castrated male rats (P<0.05, 0.01 and 0.05), increase the serum E2 and uterus index of castrated female rats (P<0.01), cut down the wet weight and dry weight of tampon granuloma in rats (P<0.01), reduce the swelling degree and swelling rate of rats with paw swelling that caused by carrageenin. Conclusion:Increase the female hormone also inhibit the secretion of male hormone, and exert the anti-inflammatory (proliferative and exudative) ef-fect, is the possibly way that CXY narrows the size and improves the inflammatory classification of acne nidus, which has a definite anti acne effect and is suitable for the clinical treatment of acne vulgaris.
