CAJ | 학술논문

目的：：观察质子泵抑制剂(PPI)联合莫沙必利、黏膜保护剂对反流性食管炎(RE)的临床疗效。方法：将136例确诊为RE的患者作为研究对象，随机分为治疗组68例和对照组68例，治疗组患者给予雷贝拉唑联合莫沙必利和黏膜保护剂治疗，对照组患者给予雷贝拉唑联合莫沙必利治疗，治疗8周后比较两组患者治疗效果。结果：治疗组患者的症状改善有效率高于对照组，差异有统计学意义(P<0.05)；经内镜检查，治疗组患者的总有效率高于对照组，差异有统计学意义(P<0.05)。结论：临床药物治疗RE时PPI联合莫沙必利、黏膜保护剂可显著提高患者的临床疗效。
목적：：관찰질자빙억제제(PPI)연합막사필리、점막보호제대반류성식관염(RE)적림상료효。방법：장136례학진위RE적환자작위연구대상，수궤분위치료조68례화대조조68례，치료조환자급여뢰패랍서연합막사필리화점막보호제치료，대조조환자급여뢰패랍서연합막사필리치료，치료8주후비교량조환자치료효과。결과：치료조환자적증상개선유효솔고우대조조，차이유통계학의의(P<0.05)；경내경검사，치료조환자적총유효솔고우대조조，차이유통계학의의(P<0.05)。결론：림상약물치료RE시PPI연합막사필리、점막보호제가현저제고환자적림상료효。
Objective:To investigate clinical efficacy of proton pump inhibitor ( PPI) combined with Mosapride, mucosal pro﹣tective drugs in reflux esophagitis ( RE) . Methods:136 cases with confirmed RE were randomly divided into two groups: PPI com﹣bined with Mosapride, mucosal protective drugs treatment group (68 cases) and PPI combined with Mosapride group (68 cases). 8 weeks after the treatment,the efficacies of the two groups were compared. Results:After 8-week treatment, the total effective rate of symptom improvement in the treatment group was significantly higher than that in the control group, and the difference was statistically significant (P<0. 05). By endoscopy, the total effective rate in the treatment group was significantly higher than that in the control group, and the difference was statistically significant (P<0. 05). Conclusions: PPI combined with Mosapride, mucosal protective drugs can raise the RE clinical efficacy significantly.