CAJ | 학술논문

目的：：比较精神分裂症患者早发性和迟发性药源性强迫症状临床特征的差异,以进一步了解药源性强迫症状。方法：采用自编调查表、CGI及自知力评定工具,调查分析723例精神分裂症患者中出现药源性强迫症状的比率、时间及药物使用情况,并对其中19例早发性药源性强迫症状患者(早发组)和43例迟发性药源性强迫症状患者(迟发组)进行分析比较。结果：①精神分裂症伴强迫症状者127例,药源性强迫症状73例,以服用氯氮平致强迫症状发生率高；②两组患者相比,迟发组患者中强迫症状荒谬性较多,对疾病的自知力较差,迟发组患者疗效差,CGI-SI评分高于早发组；③在强迫的分布上迟发组仅有强迫行为较多。结论：早发性和迟发性药源性强迫症状有不同的临床特点,后者对症状的认识较差,疗效欠佳。
목적：：비교정신분렬증환자조발성화지발성약원성강박증상림상특정적차이,이진일보료해약원성강박증상。방법：채용자편조사표、CGI급자지력평정공구,조사분석723례정신분렬증환자중출현약원성강박증상적비솔、시간급약물사용정황,병대기중19례조발성약원성강박증상환자(조발조)화43례지발성약원성강박증상환자(지발조)진행분석비교。결과：①정신분렬증반강박증상자127례,약원성강박증상73례,이복용록담평치강박증상발생솔고；②량조환자상비,지발조환자중강박증상황류성교다,대질병적자지력교차,지발조환자료효차,CGI-SI평분고우조발조；③재강박적분포상지발조부유강박행위교다。결론：조발성화지발성약원성강박증상유불동적림상특점,후자대증상적인식교차,료효흠가。
Objective:To compare differences of clinical features of early-onset ( EDO) and late-onset ( LDO) drug-induced obsessive-compulsive symptoms, in order to well understand the drug-induced obsessive-compulsive symptoms. Methods:723 schiz﹣ophrenic patients were interviewed using the self-designed questionnaire, CGI and insight assessment tool. The incidence, occurrence time and the drugs they had used were analyzed in 19 patients with EDO ( EDO group) and 43 patients with LDO ( LDO group) . Re﹣sults:(1) Of the 723 schizophrenic patients, 127 cases were identified with obsessive-compulsive symptoms, wherein 73 cases were induced by the drugs (10. 1%);The highest incidence of emergence of obsessive-compulsive symptoms was observed during the treat﹣ment with clozapine. (2) The patients with LDO showed more symptoms with forced absurdity and poorer insight of the symptoms. Their curative effect was worse than that of those with EDO. LDO group had higher CGI-SI scores than EDO group. (3) The incidence of only compulsive behavior in the patients with LDO was higher than that of those with EDO. Conclusions: There are differences in clinical features between EDO and LDO, and the latter has poor insight of the symptoms and poor curative effect.