CAJ | 학술논문

背景：膝关节骨性关节炎的发病机制至今仍不十分清楚，且缺乏早期诊断手段，但由于其多见于中老年女性群体中，推测其可能与人体内的血清雌二醇水平有密切关系。目的：探索血清雌二醇水平与女性膝骨性关节炎严重度的相关性。方法：收集2012年2月至2013年12月广西医科大学第一附属医院就诊的膝关节骨性关节炎患者76例，按绝经与否分为绝经前组(n=42)与绝经后组(n=34)，两组均参照Kelgren-Lawrence(K-L)分级标准，分为K-L 0，Ⅱ，Ⅳ级3个亚组，应用美国特种外科医院膝关节评分评定膝关节功能，采用电化学发光法检测受试者血清雌二醇水平，并进行相关性分析。结果与结论：绝经前和绝经后女性膝关节骨性关节炎患者的血清雌二醇水平均随K-L分级升高及年龄增加而减低(P <0.05)；相同K-L分级的绝经女性膝关节骨性关节炎患者的血清雌二醇水平比绝经前明显减低。线性回归分析显示，绝经前后女性膝关节骨性关节炎患者年龄与血清雌二醇水平存在负相关(R2=0.222，P <0.05)，而美国特种外科医院膝关节评分与血清雌二醇水平存在正相关(R2=0.415，P <0.05)。提示女性膝关节骨性关节炎的严重度与血清雌二醇水平呈负相关，与年龄呈正相关。
배경：슬관절골성관절염적발병궤제지금잉불십분청초，차결핍조기진단수단，단유우기다견우중노년녀성군체중，추측기가능여인체내적혈청자이순수평유밀절관계。목적：탐색혈청자이순수평여녀성슬골성관절염엄중도적상관성。방법：수집2012년2월지2013년12월엄서의과대학제일부속의원취진적슬관절골성관절염환자76례，안절경여부분위절경전조(n=42)여절경후조(n=34)，량조균삼조Kelgren-Lawrence(K-L)분급표준，분위K-L 0，Ⅱ，Ⅳ급3개아조，응용미국특충외과의원슬관절평분평정슬관절공능，채용전화학발광법검측수시자혈청자이순수평，병진행상관성분석。결과여결론：절경전화절경후녀성슬관절골성관절염환자적혈청자이순수평균수K-L분급승고급년령증가이감저(P <0.05)；상동K-L분급적절경녀성슬관절골성관절염환자적혈청자이순수평비절경전명현감저。선성회귀분석현시，절경전후녀성슬관절골성관절염환자년령여혈청자이순수평존재부상관(R2=0.222，P <0.05)，이미국특충외과의원슬관절평분여혈청자이순수평존재정상관(R2=0.415，P <0.05)。제시녀성슬관절골성관절염적엄중도여혈청자이순수평정부상관，여년령정정상관。
BACKGROUND:The pathogenesis of knee osteoarthritis is stil not very clear, and there is a lack of early diagnosis methods. Because it is more common in middle-aged women, it is suggested that the pathogenesis of knee osteoarthritis may be closely related to serum estradiol levels in the human body. OBJECTIVE:To explore the correlation between the level of serum estradiol and the severity of osteoarthritis in female patients with knee osteoarthritis. METHODS:Seventy-six female patients with knee osteoarthritis admitted in the First Affiliated Hospital of Guangxi Medical University from February 2012 to December 2013 were enroled, and divided into premenopause group (n=42) and postmenopause group (n=34). According to Kelgren-Lawrence (K-L) grading, both two groups were subdivided into K-L 0, II and IV groups. The knee function was evaluated with Hospital for Special Surgery (HSS) Knee Score Standard in USA, the serum estradiol levels were detected with electrochemiluminescence immunoassay. Then, the correlation analysis was performed. RESULTS AND CONCLUSION: The serum estradiol levels of the premenopause group and postmenopause group were decreased significantly with the increase of K-L grade and age (P < 0.05). Under the same K-L grade, the serum estradiol levels in the postmenopausal patients were significantly lower than those in the premenopausal patients. Linear regression analysis showed that there was a negative relationship between age and serum estradiol level (R2=0.222,P < 0.05), and there was a positive correlation between HSS scores and serum estradiol levels (R2=0.415,P < 0.05). The severity of knee osteoarthritis in female patients shows a negative correlation with the level of serum estradiol but a positive correlation with age.