CAJ | 학술논문

背景：在运动生理状态下，KATP 在调节冠状动脉张力、运动诱导心肌保护效应和延缓骨骼肌疲劳等多个方面具有重要作用。目的：对KATP在运动中的作用进行了综述和探讨，以期为深入了解运动调节机体代谢提供理论参考。方法：检索1991年1月至2014年6月 PubMed数据库及维普中文科技数据库文献。英文检索词为“KATP Channels；Adenosine Triphosphate；Sports；Myocardium；Ion Channels”，中文检索词为“KATP通道；三磷酸腺苷；运动；心肌；离子通道”。选择与KATP分子结构、生物学功能及调控相关，以及KATP与冠状动脉、心肌、骨骼肌疲劳及运动能力相关的文献42篇文献进行探讨。结果与结论：ATP敏感性钾离子通道可以偶联细胞内能量代谢和细胞膜兴奋性，在应对各种生理和病理应激时是保护心肌的效应器之一。长期的耐力训练则会增加骨骼肌和心肌KATP的表达，可能是心肌和骨骼肌对运动应激产生的一种适应性表现。KATP 可能参与冠状动脉血流量的调节。在运动诱导的减轻心肌缺血再灌注损伤的保护效应中，心肌KATP具有重要作用。当骨骼肌疲劳发生时，KATP的激活有利于防止ATP的过度消耗而造成肌纤维损伤和细胞死亡，有利于疲劳的快速恢复。关于KATP与运动能力的关系仍需进一步的研究。
배경：재운동생리상태하，KATP 재조절관상동맥장력、운동유도심기보호효응화연완골격기피로등다개방면구유중요작용。목적：대KATP재운동중적작용진행료종술화탐토，이기위심입료해운동조절궤체대사제공이론삼고。방법：검색1991년1월지2014년6월 PubMed수거고급유보중문과기수거고문헌。영문검색사위“KATP Channels；Adenosine Triphosphate；Sports；Myocardium；Ion Channels”，중문검색사위“KATP통도；삼린산선감；운동；심기；리자통도”。선택여KATP분자결구、생물학공능급조공상관，이급KATP여관상동맥、심기、골격기피로급운동능력상관적문헌42편문헌진행탐토。결과여결론：ATP민감성갑리자통도가이우련세포내능량대사화세포막흥강성，재응대각충생리화병리응격시시보호심기적효응기지일。장기적내력훈련칙회증가골격기화심기KATP적표체，가능시심기화골격기대운동응격산생적일충괄응성표현。KATP 가능삼여관상동맥혈류량적조절。재운동유도적감경심기결혈재관주손상적보호효응중，심기KATP구유중요작용。당골격기피로발생시，KATP적격활유리우방지ATP적과도소모이조성기섬유손상화세포사망，유리우피로적쾌속회복。관우KATP여운동능력적관계잉수진일보적연구。
BACKGROUND:In the condition of exercise physiology, adenosine triphosphate-sensitive potassium (KATP) channel plays an important role in many aspects, such as regulation of coronary artery tension, exercise-induced myocardial protection effect and delay of skeletal muscle fatigue. OBJECTIVE:To review and investigate the role of KATP in exercise in order to provide theoretical reference for understanding mechanism underlying exercise regulation of body’s metabolism. METHODS: A computer-based online search of PubMed and VIP databases was performed for articles related to molecular structure, biological function and regulatory role of KATP as wel as correlation of KATP with coronary artery, myocardium, skeletal muscle fatigue and exercise ability published from January 1991 to June 2014. The keywords were “KATP channels; adenosine triphosphate; sports; myocardium; ion channels” in English and Chinese, respectively. Finaly, 42 relevant articles were included in result analysis. RESULTS AND CONCLUSION: Coupling with celular energy metabolism and cel membrane excitability, KATP channel is one of the effectors for myocardial protection in response to various physiological and pathological stresses. Prolonged endurance training can increase the expression of skeletal muscle and myocardial KATP, which may be an adaptive performance of the myocardium and skeletal muscle in response to exercise stress. KATP may participate in regulation of coronary blood flow. Myocardial KATP plays an important protective role for aleviating myocardial ischemia-reperfusion injury induced by exercise. When skeletal muscle fatigue occurs, the activation of KATP is helpful to prevent muscle fiber damage and cel death due to excessive consumption of ATP, in favor for the fast recovery from fatigue. The relation between KATP and exercise ability stil needs further research.