CAJ | 학술논문

目的：：探讨单一使用3%的氯化钠雾化吸入佐治婴幼儿肺炎的临床疗效。方法以2011年12月~2013年12月期间我院收治的126例婴幼儿肺炎为研究对象,按随机数字表法分为三组,布地奈德组、3%氯化钠组和联合雾化组,分别纳入病例40例、44例和42例。三组在综合治疗的基础上分别使用布地奈德、3%氯化钠和布地奈德联合3%氯化钠雾化治疗,观察三组患儿雾化治疗后咳嗽、肺部湿啰音、哮鸣音症状消失时间、住院天数,并于治疗7天后评定疗效。治愈的患儿出院后随访3个月记录复发次数。结果三组患儿咳嗽、肺部湿啰音、哮鸣音等症状体征消失时间差异均有统计学意义( P<0．05)。3%的氯化钠雾化组咳嗽消失时间(6．7±2．0 d)比联合雾化组(5．2±1．5 d)慢,差异有统计学意义(P<0．05),但是与布地奈德组(6．5±1．8 d)相当,差异无统计学意义(P>0．05)；在肺部湿啰音(4．2± 1．2 d)和哮鸣音(3．2± 1．0 d)的消失时间方面和联合雾化组(3．8±0．9 d,2．9±0．8 d)相当(P>0．05),但是比布地奈德组快(4．1±1．2 d),差异有统计学意义(P<0．05)。三组患儿住院天数差异没有统计学意义(P>0．05)。三组的疗效以联合雾化组治愈率最高,但是三组间疗效比较,差异没有统计学意义(P>0．05)。对治愈患儿进行3个月随访,肺炎复发频率差异没有统计学意义(P>0．05)。结论在综合治疗的基础上使用3%氯化钠雾化吸入佐治小儿肺炎,症状消失快,疗效显著,有待于临床进一步研究证实。
목적：：탐토단일사용3%적록화납무화흡입좌치영유인폐염적림상료효。방법이2011년12월~2013년12월기간아원수치적126례영유인폐염위연구대상,안수궤수자표법분위삼조,포지내덕조、3%록화납조화연합무화조,분별납입병례40례、44례화42례。삼조재종합치료적기출상분별사용포지내덕、3%록화납화포지내덕연합3%록화납무화치료,관찰삼조환인무화치료후해수、폐부습라음、효명음증상소실시간、주원천수,병우치료7천후평정료효。치유적환인출원후수방3개월기록복발차수。결과삼조환인해수、폐부습라음、효명음등증상체정소실시간차이균유통계학의의( P<0．05)。3%적록화납무화조해수소실시간(6．7±2．0 d)비연합무화조(5．2±1．5 d)만,차이유통계학의의(P<0．05),단시여포지내덕조(6．5±1．8 d)상당,차이무통계학의의(P>0．05)；재폐부습라음(4．2± 1．2 d)화효명음(3．2± 1．0 d)적소실시간방면화연합무화조(3．8±0．9 d,2．9±0．8 d)상당(P>0．05),단시비포지내덕조쾌(4．1±1．2 d),차이유통계학의의(P<0．05)。삼조환인주원천수차이몰유통계학의의(P>0．05)。삼조적료효이연합무화조치유솔최고,단시삼조간료효비교,차이몰유통계학의의(P>0．05)。대치유환인진행3개월수방,폐염복발빈솔차이몰유통계학의의(P>0．05)。결론재종합치료적기출상사용3%록화납무화흡입좌치소인폐염,증상소실쾌,료효현저,유대우림상진일보연구증실。
Objective To investigate the clinical effect of single 3% sodium chloride inhalation in the treat-ment of infantile pneumonia. Methods 12 infants with pneumonia were randomly divided into three groups, the budesonide group, the 3% sodium chloride group and the combined inhalation group with 40 cases, 44 cases and 42 cases respectively. The three groups were treated with budesonide, 3% sodium chloride and budesonide combined with 3% sodium chloride aerosol respectively on the basis of comprehensive therapy. The disappeared time of cough, lung wet rales and wheeze symptoms of the three groups after atomization treatment were observed. The duration of hospital stay of the three groups was recorded, and the efficacy was evaluated 7 days after the treatment. The cured children of the three groups were followed-up for 3 months after hospital discharge and recurrence times were recor- ded. Results There were significant differences in disappeared time of cough, lung wet rales and wheezing symp-toms among the three groups (P<0. 05). The cough disappeared time (6. 7 ± 2. 0 d) was longer in the 3% sodium chloride group than in the combined inhalation group (5. 2 ± 1. 5d) (P<0. 05), but there was no significant differ-ence between the 3% sodium chloride group and the budesonide group (6. 5 ± 1. 8d) (P>0. 05). The disappearing time of lung wet rales (4. 2 ± 1. 2d) and wheeze (3. 2 ± 1. 0d) in the 3% sodium chloride group was roughly same as the combined inhalation group (3. 8 ± 0. 9d, 2. 9 ± 0. 8d), but it was shorter than in the budesonide group (4. 1 ± 1. 2 d) (P<0. 05). There was no significant difference in the duration of hospital stay among the three groups (P>0. 05). The cure rate was the highest in the combined inhalation group. However, the efficacy showed no significant difference among the three groups (P>0. 05). There was no significant difference in the recurrent frequency of pneu-monia among the three groups during follow-ups ( P>0. 05 ) . Conclusion 3% sodium chloride inhalation on the basis of comprehensive therapy has obvious curative effect and can quickly relieve the clinical symptoms in the treat-ment of infants with pneumonia.