CAJ | 학술논문

目的：探讨噻托溴铵联合沙美特罗/丙酸氟替卡松联合治疗稳定期慢性阻塞性肺疾病( COPD)的临床效果。方法采用随机的方法将93例稳定期COPD患者分为观察组(47例)和对照组(46例),两组均予常规基础治疗,观察组给予沙美特罗/丙酸氟替卡松(50μg/500μg,2次/d)联合噻托溴铵(18μg,1次/d)吸入治疗,对照组给予沙美特罗/丙酸氟替卡松(50μg/500μg,2次/d)单独吸入治疗,疗程为9个月。观察患者治疗前与治疗后12、24、36周运动耐量、呼吸困难评分以及肺功能的变化。结果治疗后两组患者6 min步行距离(6MWD)值、肺功能均有显著增加(P<0．05),呼吸困难评分(MRC)均有显著下降(P<0．05),而观察组各项指标改善明显优于对照组(P<0．05)。结论沙美特罗/丙酸氟替卡松单用可有效缓解稳定期COPD患者的临床症状、改善肺功能。而沙美特罗/丙酸氟替卡松联合噻托溴铵在减轻患者临床症状,改善肺功能上的作用更为显著,值得临床推广应用。
목적：탐토새탁추안연합사미특라/병산불체잡송연합치료은정기만성조새성폐질병( COPD)적림상효과。방법채용수궤적방법장93례은정기COPD환자분위관찰조(47례)화대조조(46례),량조균여상규기출치료,관찰조급여사미특라/병산불체잡송(50μg/500μg,2차/d)연합새탁추안(18μg,1차/d)흡입치료,대조조급여사미특라/병산불체잡송(50μg/500μg,2차/d)단독흡입치료,료정위9개월。관찰환자치료전여치료후12、24、36주운동내량、호흡곤난평분이급폐공능적변화。결과치료후량조환자6 min보행거리(6MWD)치、폐공능균유현저증가(P<0．05),호흡곤난평분(MRC)균유현저하강(P<0．05),이관찰조각항지표개선명현우우대조조(P<0．05)。결론사미특라/병산불체잡송단용가유효완해은정기COPD환자적림상증상、개선폐공능。이사미특라/병산불체잡송연합새탁추안재감경환자림상증상,개선폐공능상적작용경위현저,치득림상추엄응용。
Objective To investigate the clinical effect of Tiotropium combined with salmeterol/fluticasone propionate in the treatment of stable chronic obstructive pulmonary disease ( COPD) . Methods 93 stable COPD pa-tients were randomly divided into the observation group (47 cases) and the control group (46 cases). All patients were given regular treatment. The observation group was treated with salmeterol/fluticasone propionate (50/500μg, inhalation, twice a day) plus Tiotropium (18μg, inhalation, once daily), and the control group was treated only with salmeterol/fluticasone propionate (50/500μg, inhalation, twice a day). The course of treatment was 9 months. 6-minute walk distance (6MWD), dyspnea scores and pulmonary function were measured before and 12, 24 and 36 weeks after treatment. Results After the treatment, 6MWD and pulmonary function increased significantly ( P<0. 05), and dyspnea scores decreased significantly in both groups, but the improvement was more pronounced in the treatment group than in the control group (P<0. 05). Conclusion Salmeterol/fluticasone propionate alone can re-lieve their clinical symptoms and improve lung function in the stable COPD patients, but salmeterol/fluticasone propi-onate combined with Tiotropium bromide can greatly relieve their clinical symptoms and improve lung function.