临床肺科杂志
臨床肺科雜誌
림상폐과잡지
JOUNAL OF CLINICAL PULMONARY MEDICINE
2015年
1期
62-64
,共3页
COPD%急性加重%血管内皮因子%诊断
COPD%急性加重%血管內皮因子%診斷
COPD%급성가중%혈관내피인자%진단
COPD%acute exacerbation%vascular endothelial factor%diagnosis
目的：探究血管内皮因子在急性加重期COPD老年患者病情诊断评估中的临床意义。方法选取2013年1月~2014年1月我院收治的急性加重期COPD患者80例为加重组,其中分为浓痰组与非浓痰组各40例、稳定期COPD患者40例为稳定组以及同期健康体检者40例为对照组,分别检测入院第1天所有研究对象的血管内皮因子( VEGF)、血清降钙素原( PCT)、超敏C-反应蛋白( hs-CRP)、肿瘤坏死因子α( TNF-α)及内皮素1(ET-1),并于入院1周后重复检测加重组上述各指标,同时分别于入院第1天和入院1周后检查加重组患者的APACHEⅢ评分。结果浓痰组的VEGF、PCT、TNF-α均高于其他三组, hs-CRP高于稳定组和对照组；非浓痰组的VEGF、hs-CRP、TNF-α高于稳定组和对照组；稳定组的VEGF高于对照组；P<0．05。治疗1周后,浓痰组患者的VEGF、PCT检测值相比治疗前均有所下降,而非浓痰组VEGF检测值相比治疗前有所下降,P<0．05。急性加重组患者的VEGF检测值与APACHEⅢ评分呈正相关,P<0．05。结论 VEGF在临床急性加重期COPD的诊断及疗效评价中具有重要作用,值得推广。
目的：探究血管內皮因子在急性加重期COPD老年患者病情診斷評估中的臨床意義。方法選取2013年1月~2014年1月我院收治的急性加重期COPD患者80例為加重組,其中分為濃痰組與非濃痰組各40例、穩定期COPD患者40例為穩定組以及同期健康體檢者40例為對照組,分彆檢測入院第1天所有研究對象的血管內皮因子( VEGF)、血清降鈣素原( PCT)、超敏C-反應蛋白( hs-CRP)、腫瘤壞死因子α( TNF-α)及內皮素1(ET-1),併于入院1週後重複檢測加重組上述各指標,同時分彆于入院第1天和入院1週後檢查加重組患者的APACHEⅢ評分。結果濃痰組的VEGF、PCT、TNF-α均高于其他三組, hs-CRP高于穩定組和對照組；非濃痰組的VEGF、hs-CRP、TNF-α高于穩定組和對照組；穩定組的VEGF高于對照組；P<0．05。治療1週後,濃痰組患者的VEGF、PCT檢測值相比治療前均有所下降,而非濃痰組VEGF檢測值相比治療前有所下降,P<0．05。急性加重組患者的VEGF檢測值與APACHEⅢ評分呈正相關,P<0．05。結論 VEGF在臨床急性加重期COPD的診斷及療效評價中具有重要作用,值得推廣。
목적：탐구혈관내피인자재급성가중기COPD노년환자병정진단평고중적림상의의。방법선취2013년1월~2014년1월아원수치적급성가중기COPD환자80례위가중조,기중분위농담조여비농담조각40례、은정기COPD환자40례위은정조이급동기건강체검자40례위대조조,분별검측입원제1천소유연구대상적혈관내피인자( VEGF)、혈청강개소원( PCT)、초민C-반응단백( hs-CRP)、종류배사인자α( TNF-α)급내피소1(ET-1),병우입원1주후중복검측가중조상술각지표,동시분별우입원제1천화입원1주후검사가중조환자적APACHEⅢ평분。결과농담조적VEGF、PCT、TNF-α균고우기타삼조, hs-CRP고우은정조화대조조；비농담조적VEGF、hs-CRP、TNF-α고우은정조화대조조；은정조적VEGF고우대조조；P<0．05。치료1주후,농담조환자적VEGF、PCT검측치상비치료전균유소하강,이비농담조VEGF검측치상비치료전유소하강,P<0．05。급성가중조환자적VEGF검측치여APACHEⅢ평분정정상관,P<0．05。결론 VEGF재림상급성가중기COPD적진단급료효평개중구유중요작용,치득추엄。
Objective To explore the clinical significance of vascular endothelial factor in the assessment of AECOPD patients. Methods The study selected 80 patients with AECOPD, which were evenly divided into the spu-tum group and the non-sputum group, 40 stable COPD patients, and 40 healthy controls. VEGF, PCT, and hs-CRP were detected at the first day on admission and 1 week after in all patients. At the same time, APACHEⅢscore was evaluated. Results On admission, the levels of VEGF and PCT were the highest in the sputum group, followed by the non-sputum group, the stable COPD group and the control group. The level of hs-CRP was higher in the sputum group than in the stable COPD group and the control group. 1 week after the treatment, the levels of VEGF and hs-CRP decreased obviously in the sputum group, and the level of VEGF decreased in the non-sputum group ( P <0. 05). The level of VEGF was positively correlated with APACHE Ⅲ scores (P <0. 05). Conclusion VEGF plays an important role in the diagnosis and evaluation of AECOPD patients.
