CAJ | 학술논문

目的：利用Meta分析评价特比萘芬与伊曲康唑治疗甲真菌病的疗效。方法检索Cochrane图书馆、Pubmed数据库、中国生物医学文献数据库、CNKI数据库、VIP数据库、万方数据库等，纳入特比萘芬与伊曲康唑对比治疗甲真菌病的随机对照试验（RCT），进行方法学质量评价，并采用RevMan5.2软件进行统计分析。结果8篇RCT文献纳入本项研究，累计病例1208例。Meta分析结果显示，特比萘芬对提高痊愈率[OR1.97；95％CI（1.27，3.07），P＜0.01]具有明显差异，而在有效率[OR 1.32；95％CI（0.86，2.03），P＞0.05]和不良反应[OR 1.01；95％CI（0.76，1.33），P＞0.05]方面则无明显差异。结论特比萘芬在治疗甲真菌病中疗效确切，是治疗甲真菌病的有效方法。
목적：이용Meta분석평개특비내분여이곡강서치료갑진균병적료효。방법검색Cochrane도서관、Pubmed수거고、중국생물의학문헌수거고、CNKI수거고、VIP수거고、만방수거고등，납입특비내분여이곡강서대비치료갑진균병적수궤대조시험（RCT），진행방법학질량평개，병채용RevMan5.2연건진행통계분석。결과8편RCT문헌납입본항연구，루계병례1208례。Meta분석결과현시，특비내분대제고전유솔[OR1.97；95％CI（1.27，3.07），P＜0.01]구유명현차이，이재유효솔[OR 1.32；95％CI（0.86，2.03），P＞0.05]화불량반응[OR 1.01；95％CI（0.76，1.33），P＞0.05]방면칙무명현차이。결론특비내분재치료갑진균병중료효학절，시치료갑진균병적유효방법。
Objective To evaluate the efficacy and safety of terbinafine versus itraconazole for onycho?mycosis through meat-analysis. Methods The studies involving randomized controlled trials (RCTs) were col?lected from the database, including Cochrane Library, Pubmed, CBMdisc, CNKI, VIP database and Wangfang database from the year of database creation to January 2014. After evaluation of the methodology on the studies included, the statistics was conducted using software RevMan5.2. Results Eight RCTs were eligibly identi?fied, which included 1 208 cases. Meta-analysis showed that terbinafine in the treatment of onychomycosis had led to higher cure rate (OR=1.97; 95%CI: 1.27, 3.07, P<0.01), yet the effective rate(OR=1.32;95%CI:0.86, 2.03, P>0.05) and adverse effects(OR=1.01;95%CI: 0.76, 1.33, P>0.05) remained no significance as compared with itraconazole. Conclusion Terbinafine can be effective in treatment of onychomycosis.