CAJ | 학술논문

目的：观察急性呼吸窘迫综合征(ARDS)患者肺泡灌洗液中白细胞介素-6(IL-6)、白细胞介素-8(IL-8)及肿瘤坏死因子-α(TNF-α)水平在血必净治疗前后的变化。方法选择我院住院的ARDS患者44例，随机分为两组，每组22例，对照组给予常规治疗，实验组在常规治疗上加用血必净，两组在治疗前、治疗后7天及治疗后14天检测肺泡灌洗液中IL-6、IL-8及TNF-α的水平变化。结果两组患者肺泡灌洗液促炎因子IL-6、IL-8及TNF-α水平在治疗前无统计学差异( P>0．05)。治疗后7天及治疗后14天，实验组的IL-6、IL-8及TNF-α水平明显低于对照组(P<0．05)。结论肺泡灌洗液中IL-6、IL-8联合TNF-α水平的检测对评估ARDS患者病情的严重程度及监测治疗结果、评估预后结果有一定参考价值。
목적：관찰급성호흡군박종합정(ARDS)환자폐포관세액중백세포개소-6(IL-6)、백세포개소-8(IL-8)급종류배사인자-α(TNF-α)수평재혈필정치료전후적변화。방법선택아원주원적ARDS환자44례，수궤분위량조，매조22례，대조조급여상규치료，실험조재상규치료상가용혈필정，량조재치료전、치료후7천급치료후14천검측폐포관세액중IL-6、IL-8급TNF-α적수평변화。결과량조환자폐포관세액촉염인자IL-6、IL-8급TNF-α수평재치료전무통계학차이( P>0．05)。치료후7천급치료후14천，실험조적IL-6、IL-8급TNF-α수평명현저우대조조(P<0．05)。결론폐포관세액중IL-6、IL-8연합TNF-α수평적검측대평고ARDS환자병정적엄중정도급감측치료결과、평고예후결과유일정삼고개치。
Objective To observe the changes of IL-6, IL-8 and TNF-α in bronchoalveolar lavage fluid of patients with ARDS patients treated with Xuebijing. Methods 44 patients with ARDS were randomly divided into 2 groups, the experimental group (22 cases) and the control group (22 cases). All patients were given routine treat-ment, and the experimental group was additionally treated with Xuebijing. The levels of IL-6, IL-8 and TNF-α in bronchoalveolar lavage fluid were detected before and 7 and 14 days after the treatment in the two groups. Results The levels of IL-6, IL-8 and TNF-αhad no significant difference in the two groups before the treatment (P>0. 05), but they were obviously lower in the experimental group than in the control group 7 and 14 days after the treatment ( P<0. 05). Conclusion The combined detection of IL-6, IL-8 and TNF-αin bronchoalveolar lavage fluid has a cer-tain significance on the evaluation and prognosis of ARDS patients.