CAJ | 학술논문

目的：研究干扰素类型在低病毒载量慢性丙型肝炎抗病毒治疗应答的影响。方法选择120例慢性丙型肝炎患者为研究对象，将120例患者分为聚乙二醇干扰素α-2a（派罗欣，Peg-IFN）组58例和普通干扰素α2b（凯因益生）组62例。所有患者用干扰素联合利巴韦林抗病毒治疗。Peg-IFN组选用180μg每周注射1次，普通干扰素组为600 MU隔日注射1次。利巴韦林使用剂量900~1200mg/d。疗程：达RVR之后再应用24周；达EVR之后再应用36周；对于12周未达EVR者再应用48周。对抗病毒治疗的应答情况与干扰素类型及丙肝病毒载量的关系进行回顾性分析。结果两组中，普通干扰素组RVR获得率为79％，EVR获得率为85.4％，派罗欣组的RVR获得率为81％，EVR获得率为89.6％。对于RVR的获得，χ2=0.009，P＞0.05，对于EVR的获得，χ2=0.036，P＞0.05，对于SVR的获得，χ2=0.010，P＞0.05，组间比较差异无统计学意义。结论在病毒载量较低的情况下，聚乙二醇干扰素α-2a与普通干扰素α-2b抗病毒治疗的RVR、EVR、SVR获得率差异无统计学意义。
목적：연구간우소류형재저병독재량만성병형간염항병독치료응답적영향。방법선택120례만성병형간염환자위연구대상，장120례환자분위취을이순간우소α-2a（파라흔，Peg-IFN）조58례화보통간우소α2b（개인익생）조62례。소유환자용간우소연합리파위림항병독치료。Peg-IFN조선용180μg매주주사1차，보통간우소조위600 MU격일주사1차。리파위림사용제량900~1200mg/d。료정：체RVR지후재응용24주；체EVR지후재응용36주；대우12주미체EVR자재응용48주。대항병독치료적응답정황여간우소류형급병간병독재량적관계진행회고성분석。결과량조중，보통간우소조RVR획득솔위79％，EVR획득솔위85.4％，파라흔조적RVR획득솔위81％，EVR획득솔위89.6％。대우RVR적획득，χ2=0.009，P＞0.05，대우EVR적획득，χ2=0.036，P＞0.05，대우SVR적획득，χ2=0.010，P＞0.05，조간비교차이무통계학의의。결론재병독재량교저적정황하，취을이순간우소α-2a여보통간우소α-2b항병독치료적RVR、EVR、SVR획득솔차이무통계학의의。
Objective To observe the response of chronic hepatitis C patients with low viral load to anti?viral treatment by different interferon(IFN) modality. Methods 120 patients with chronic hepatitis C were as?signed to Peg-IFN group(n=58, treated with Peginterferon alfa-2a injection in dose of 180μg once a week) and recombinant human interferon α-2b injection group(n=62, administered in dose of 600 MU once every other day), and the two groups were given additional dosage of ribavirin by 900~1200 mg/d. The treatment course was as follows:24 weeks were extended after rapid virological response(RVR), and 36 weeks after early virological response(EVR). For patients failed to meet EVR by the 12th week, 48 weeks were extended. The data were retrospectively analyzed on response to antiviral treatment, interferon modality and final viral load af?ter treatment. Results RVR and EVR were 79%and 85.4%for the patients treated with recombinant human interferon α-2b injection, and 81%, and 89.6 % for Peg-IFN group, respectively(χ2 = 0.009, P>0.05; χ2 =0.036, P>0.05). There was no significance between groups regarding sustained virological response(SVR)(χ2=0.010, P>0.05). Conclusion Interferon α-2b and pegylated interferon α-2a may produce similar effects on chronic hepatitis C patients with lower viral load by statistical estimation of RVR, EVR and SVR.