CAJ | 학술논문

目的：探讨儿童深部真菌感染情况，分析其对常用抗真菌药物的敏感性，为真菌感染的治疗和预防提供依据。方法回顾性分析了2009年3月~2012年12月延安市某医院270例确诊为深部真菌感染住院患儿的临床资料，药敏试验严格按照2006年CLSI M272A2规则及标准进行AmB、FCZ、5－FC、ICZ 4种抗真菌药敏检测。结果真菌感染标本主要来源于咽拭子，白假丝酵母菌的分离率最高(61.1%)，其次为光滑假丝酵母菌、热带假丝酵母菌、近平滑假丝酵母菌和克柔假丝酵母菌。药敏实验结果表明，假丝酵母菌对AmB、5－FC的敏感性较高。结论儿科患者中分离的真菌中以假丝酵母菌属最多，并以白假丝酵母菌为主；AmB、5－FC均有较高的抗真菌活性。应加强对临床真菌感染与耐药性情况的监测，以指导临床合理使用抗生素。
목적：탐토인동심부진균감염정황，분석기대상용항진균약물적민감성，위진균감염적치료화예방제공의거。방법회고성분석료2009년3월~2012년12월연안시모의원270례학진위심부진균감염주원환인적림상자료，약민시험엄격안조2006년CLSI M272A2규칙급표준진행AmB、FCZ、5－FC、ICZ 4충항진균약민검측。결과진균감염표본주요래원우인식자，백가사효모균적분리솔최고(61.1%)，기차위광활가사효모균、열대가사효모균、근평활가사효모균화극유가사효모균。약민실험결과표명，가사효모균대AmB、5－FC적민감성교고。결론인과환자중분리적진균중이가사효모균속최다，병이백가사효모균위주；AmB、5－FC균유교고적항진균활성。응가강대림상진균감염여내약성정황적감측，이지도림상합리사용항생소。
Objective To investigate the status of deep fungal infection in children, and analyze its sen?sitivity to first-line antibiotics for evidence to treat fungal infection. Methods The clinical data were retrospec?tively analyzed in 270 child inpatients with deep fungal infection undergone treatment in a hospital of Yanan area between March 2009 and December 2012. Antifungal susceptibility testing, including amphotericin B (AmB), fluconazole(FCZ), 5-flucytosine(5-FC) and itraconazole(ICZ) was performed in accordance with Clinical and Laboratory Standards Institute(CLSI) document M27-A2. Results The specimens obtained pri?marily using the nasopharyngeal swabs were isolated, and the results showed that Candida albicans was the highest(61.1%), followed by Candida glabrata,Candida tropicalis,Candida parapsilosis and Candida krusei. Drug sensitive test revealed that Candida albicans was highly sensitive to AmB and 5-FC. Conclusion Deep fungal infection is primarily associated with Candida, especially Candida albicans, and AmB and 5-FC have higher antifungal sensitivity. Surveillance shall be strengthened over the fungal infection and drug-resistance for reasonable use of antibiotics in clinic.