CAJ | 학술논문

赖氨酸特异性组蛋白去甲基化酶（LSD1）是一个黄素腺嘌呤二核苷酸（FAD）依赖性单胺氧化酶，它能够特异性脱去单甲基化和二甲基化 H3 K4和 H3 K9位点上的甲基基团，从而调节基因的转录活性。 LSD1对哺乳动物的发育至关重要，并参与许多生物学过程，包括细胞类型的分化、基因活化和基因抑制。目前证实LSD1可促进细胞相变（缺乏LSD1导致部分细胞周期阻滞在G2／M期）和细胞增殖，提示其过表达可促进肿瘤的发生。 LSD1作为一种去甲基化酶，有可能成为一个新的抗肿瘤治疗靶点。现对LSD1的结构、作用方式以及其与肿瘤发生的关系等方面进行综述。
뢰안산특이성조단백거갑기화매（LSD1）시일개황소선표령이핵감산（FAD）의뢰성단알양화매，타능구특이성탈거단갑기화화이갑기화 H3 K4화 H3 K9위점상적갑기기단，종이조절기인적전록활성。 LSD1대포유동물적발육지관중요，병삼여허다생물학과정，포괄세포류형적분화、기인활화화기인억제。목전증실LSD1가촉진세포상변（결핍LSD1도치부분세포주기조체재G2／M기）화세포증식，제시기과표체가촉진종류적발생。 LSD1작위일충거갑기화매，유가능성위일개신적항종류치료파점。현대LSD1적결구、작용방식이급기여종류발생적관계등방면진행종술。
Lysine specific demethylase 1( LSD1) is a kind of flavin adenine dinucleotid ( FAD) dependent amine oxidase and can specifically demethylate H 3K4me2/me1 and H3K9me2/mel, thus it can regulate gene transcriptional activity .LSD1 is essential for mammalian development and is involved in many biological proces-ses,including cell differentiation,gene activation,and gene repression.Nowadays,it is demonstrated that LSD1 might promote cell phase transition(deficiency in LSD1 leads to partial cell cycle arrest in G2/M)and cell prolif-eration,suggesting that the over -expression of LSD1 might promote tumorigenesis.LSD1,as a demethylase,may be a new target for anti -cancer therapy.Hereby,we review on the structure,action mode of LSD1 and its rela-tionship with oncogenesis .