CAJ | 학술논문

目的：研究Caveolin－1在非小细胞肺癌（ NSCLC）中的表达，探讨Caveolin－1的表达与肺癌表皮生长因子受体（ EGFR）突变的关系。方法运用免疫组织化学法检测哈尔滨医科大学附属肿瘤医院40例NSCLC组织中Caveolin－1表达，同时应用ARMS－qPCR方法检测EGFR突变情况，并结合患者的临床病理特征和相关性进行分析。结果 Caveolin－1在NSCLC组织中阳性表达率显著低于正常肺组织，NSCLC组织中Caveolin－1表达与组织学类型相关，同时与EGFR突变呈负相关，差异有统计学意义（P＜0．05）。结论 Caveolin－1表达与EGFR突变在NSCLC中呈负相关，与组织学类型密切相关，可能成为诊断和判定NSCLC临床预后的重要分子指标。
목적：연구Caveolin－1재비소세포폐암（ NSCLC）중적표체，탐토Caveolin－1적표체여폐암표피생장인자수체（ EGFR）돌변적관계。방법운용면역조직화학법검측합이빈의과대학부속종류의원40례NSCLC조직중Caveolin－1표체，동시응용ARMS－qPCR방법검측EGFR돌변정황，병결합환자적림상병리특정화상관성진행분석。결과 Caveolin－1재NSCLC조직중양성표체솔현저저우정상폐조직，NSCLC조직중Caveolin－1표체여조직학류형상관，동시여EGFR돌변정부상관，차이유통계학의의（P＜0．05）。결론 Caveolin－1표체여EGFR돌변재NSCLC중정부상관，여조직학류형밀절상관，가능성위진단화판정NSCLC림상예후적중요분자지표。
Objective This study aims to examine expression of Caveolin -1 in non smoking cell lung cancer(NSCLC)and to discusses the relationship between expression of Caveolin -1 and the Epidermal growth factor receptor mutations .Methods Immunohistochemical staining was used to determine the Caveolin -1 ex-pression and ARMS-qPCR was used to measure EGFR mutations in 40 cases of lung cancer tissue .The clinical pathological characteristics and correlations in patients were analyzed .Results The expression of Caveolin -1 in human lung cancer was significantly lower than that in normal lung tissue ,and negatively correlated with EGFR mutations ,which was statistically significant .Conclusion Caveolin -1 expression is negatively correlated with EGFR mutations in non-small cell lung cancer and related to the histologic type .Caveolin-1 may be a molecu-lar target for diagnosis and judgment of NSCLC .