CAJ | 학술논문

介绍了一种环氧虫啶的合成新方法。以硝基二氯乙烯为原料，先通过硝化得到二甲氧基硝基乙烯，经环合反应合成硝基亚甲基咪唑烷，再经过缩合反应制得重要中间体氯吡啶硝基亚甲基咪唑烷，最后与丁二醛通过成环反应合成环氧虫啶。该合成工艺原料易得，操作简便，反应条件温和，产品含量97%，具有工业化应用前景。
개소료일충배양충정적합성신방법。이초기이록을희위원료，선통과초화득도이갑양기초기을희，경배합반응합성초기아갑기미서완，재경과축합반응제득중요중간체록필정초기아갑기미서완，최후여정이철통과성배반응합성배양충정。해합성공예원료역득，조작간편，반응조건온화，산품함량97%，구유공업화응용전경。
A novel synthetic route of cycloxaprid was developed. Using 1,1-dichloro-2-nitroethene as the starting material, 1,1-dimethoxy-2-nitroethene was obtainedvia nitration reaction. Followed by cyclization and condensation, the key intermediate 2-chloro-5-chloromethylpyridine (CCMP) was formed. The target compound was synthesized by reacting with CCMP and succindialdehyde. The new synthetic process had advantages of readily available raw materials, simple operations, mild reaction conditions. And the purity of the product was 97%. It was valuable to be used in industrial scale.