CAJ | 학술논문

目的：探讨人参皂甙Rg3联合槐耳颗粒对免疫抑制小鼠免疫功能的影响。方法实验小鼠随机分为正常对照组、环磷酰胺模型组、人参皂甙Rg3组以及联合用药组（人参皂甙Rg3＋槐耳颗粒）。正常对照组腹腔注射生理盐水，其余各组注射环磷酰胺建立免疫低下模型。正常对照组与模型组每日灌胃生理盐水，人参皂甙Rg3组每日灌胃200mg／kg人参皂甙Rg3，联合用药组每日灌胃100mg／kg人参皂甙Rg3和900mg／kg槐耳颗粒，7d后测定小鼠免疫功能。结果与模型组比，人参皂甙Rg3组及联合用药组的脾指数、胸腺指数、吞噬指数、血清溶血素含量、淋巴细胞转化率明显提高，联合用药组效果更显著。结论人参皂甙 Rg3联合应用槐耳颗粒可改善免疫抑制小鼠的免疫功能，两种药物有一定的协同辅助作用。
목적：탐토인삼조대Rg3연합괴이과립대면역억제소서면역공능적영향。방법실험소서수궤분위정상대조조、배린선알모형조、인삼조대Rg3조이급연합용약조（인삼조대Rg3＋괴이과립）。정상대조조복강주사생리염수，기여각조주사배린선알건립면역저하모형。정상대조조여모형조매일관위생리염수，인삼조대Rg3조매일관위200mg／kg인삼조대Rg3，연합용약조매일관위100mg／kg인삼조대Rg3화900mg／kg괴이과립，7d후측정소서면역공능。결과여모형조비，인삼조대Rg3조급연합용약조적비지수、흉선지수、탄서지수、혈청용혈소함량、림파세포전화솔명현제고，연합용약조효과경현저。결론인삼조대 Rg3연합응용괴이과립가개선면역억제소서적면역공능，량충약물유일정적협동보조작용。
Objective To investigate the immunoregulation effect of Ginsenoside Rg 3 combined with Huaier on immunosuppression mice induced by cyclophosphamide (CTX ) .Methods ICR mice were randomly divided into four groups:control group ,CTX model group ,Ginsenoside Rg3 group ,Ginsenoside Rg3 combined with Huaier group .The mice in control group received intraperitoneal injection of physiological saline and the other three groups received intraperitoneal injection of CTX (40 mg/kg once a day for 3 days from the 4th day beginning ) to induce immunosuppression .The control group and the model group received intragastric administration of physio‐logical saline daily and Ginsenoside Rg3 group received Ginsenoside Rg3 treatment(200mg/kg orally once a day for 7 days respectively ) ,Huaier combined with Ginsenoside Rg3 group received 100mg/kg Ginsenoside Rg3 and 900mg/kg Huaier treatment (orally once a day for 7 days respectively ) .After 7 days ,the phagocytosis of macro‐phage ,the content of serum hemolysin ,lymphocyte transformation rate ,spleen index and thymus index were ana‐lyzed .Results CTX‐treated mice showed significant decrease in the number of the phagocytosis of macrophage , hemolysin content ,lymphocyte transformation rate ,spleen index ,thymus index .Ginsenoside Rg3 combined with Huaier significantly increased the number of the phagocytosis of macrophage ,hemolysin content ,lymphocyte trans‐formation rate ,spleen index ,thymus index .Conclusion Ginsenoside Rg3 combined with Huaier can notably im‐prove the immune function in immuno‐depressed mice induced by CTX .