2,3,4,5-四氢-5-甲基-1H-吡啶并[4,3-b]吲哚-1-酮的合成研究
2,3,4,5-사경-5-갑기-1H-필정병[4,3-b]신타-1-동적합성연구
Synthesis of 2, 3, 4, 5-tetrahydro-5-methyl-1H-pyrido[4, 3-b] indol-1-one
  • 万方数据
    兰州大学学报（自然科学版） 란주대학학보（자연과학판）
    JOURNAL OF LANZHOU UNIVERSITY（NATURAL SCIENCES）
    2014年 6期 902-906 ,共5页

    李春新%陈立福%霍利春%刘生丽

    리춘신%진립복%곽리춘%류생려

    哌啶二酮%吲哚%盐酸阿洛司琼%合成%高产率 哌啶二酮%吲哚%鹽痠阿洛司瓊%閤成%高產率
    고정이동%신타%염산아락사경%합성%고산솔
    piperidinedione%indole%alosetron hydrochloride%synthesis%high yield
    探索了以丙二酸单乙酯、3-氨基丙酸乙酯盐酸盐为原料合成2,4-哌啶二酮,再与N-甲基-2-苯肼反应生成目标分子2,3,4,5-四氢-5-甲基-1H-吡啶并[4,3-b]吲哚-1-酮和盐酸阿洛司琼的合成方法,总收率为30.2%.此方法反应速率快、产率高、适用于大规模生产.
    탐색료이병이산단을지、3-안기병산을지염산염위원료합성2,4-고정이동,재여N-갑기-2-분정반응생성목표분자2,3,4,5-사경-5-갑기-1H-필정병[4,3-b]신타-1-동화염산아락사경적합성방법,총수솔위30.2%.차방법반응속솔쾌、산솔고、괄용우대규모생산.
    The synthesis method was used to obtain 2, 3, 4, 5-tetrahydro-5-methyl-1H-pyrido[4, 3-b]indol-1-one and alosetron hydrochloride from N-methyl-2-phenylhydrazine and 2, 4-piperidine-dione was synthesized with malonate and 3-amino-propionic acid ethyl ester hydrochloride. The overall yield of the compound was 30.2%The methods had a rapid reaction rate, high yield and were applicable in industrial production.
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