肿瘤基础与临床
腫瘤基礎與臨床
종류기출여림상
JOURNAL OF BASIC AND CLINICAL ONCOLOGY
2014年
6期
509-511
,共3页
氟比洛芬酯%曲马多%地佐辛%患者自控镇痛%胸腔镜
氟比洛芬酯%麯馬多%地佐辛%患者自控鎮痛%胸腔鏡
불비락분지%곡마다%지좌신%환자자공진통%흉강경
flurbiprofen axetil%tramadol%dezocine%patient controlled analgesia%thorascopic surgery
目的：比较地佐辛与氟比洛芬酯或曲马多联合用于肺癌胸腔镜手术术后镇痛的效果及安全性。方法择期行胸腔镜下肺癌根治术患者60例随机均分为2组，每组30例，手术结束前30 min给予负荷量地佐辛0.1~0.15 mg·kg-1、托烷司琼6 mg。术后接患者自控静脉镇痛泵（2 mL·h-1）。地佐辛复合氟比洛芬酯组（ A组）镇痛泵配方为地佐辛0.5 mg·kg-1加氟比洛芬酯3 mg·kg-1，地佐辛复合曲马多组（ B组）为地佐辛0.5 mg·kg-1加曲马多10 mg·kg-1，2组均加托烷司琼6 mg。记录患者术后2、4、12、24、48 h的VAS疼痛评分、术后48 h内的按压次数和毒副反应。结果2组患者均获得良好的镇痛效果，术后各时间点的VAS评分及术后48 h患者自控静脉镇痛泵按压次数比较差异均无统计学意义（ P均>0.05）；B组恶心呕吐发生率显著高于A组（P<0.05）。结论在肺癌胸腔镜手术术后镇痛中，地佐辛复合氟比洛芬酯毒副反应轻且镇痛良好。
目的：比較地佐辛與氟比洛芬酯或麯馬多聯閤用于肺癌胸腔鏡手術術後鎮痛的效果及安全性。方法擇期行胸腔鏡下肺癌根治術患者60例隨機均分為2組，每組30例，手術結束前30 min給予負荷量地佐辛0.1~0.15 mg·kg-1、託烷司瓊6 mg。術後接患者自控靜脈鎮痛泵（2 mL·h-1）。地佐辛複閤氟比洛芬酯組（ A組）鎮痛泵配方為地佐辛0.5 mg·kg-1加氟比洛芬酯3 mg·kg-1，地佐辛複閤麯馬多組（ B組）為地佐辛0.5 mg·kg-1加麯馬多10 mg·kg-1，2組均加託烷司瓊6 mg。記錄患者術後2、4、12、24、48 h的VAS疼痛評分、術後48 h內的按壓次數和毒副反應。結果2組患者均穫得良好的鎮痛效果，術後各時間點的VAS評分及術後48 h患者自控靜脈鎮痛泵按壓次數比較差異均無統計學意義（ P均>0.05）；B組噁心嘔吐髮生率顯著高于A組（P<0.05）。結論在肺癌胸腔鏡手術術後鎮痛中，地佐辛複閤氟比洛芬酯毒副反應輕且鎮痛良好。
목적：비교지좌신여불비락분지혹곡마다연합용우폐암흉강경수술술후진통적효과급안전성。방법택기행흉강경하폐암근치술환자60례수궤균분위2조，매조30례，수술결속전30 min급여부하량지좌신0.1~0.15 mg·kg-1、탁완사경6 mg。술후접환자자공정맥진통빙（2 mL·h-1）。지좌신복합불비락분지조（ A조）진통빙배방위지좌신0.5 mg·kg-1가불비락분지3 mg·kg-1，지좌신복합곡마다조（ B조）위지좌신0.5 mg·kg-1가곡마다10 mg·kg-1，2조균가탁완사경6 mg。기록환자술후2、4、12、24、48 h적VAS동통평분、술후48 h내적안압차수화독부반응。결과2조환자균획득량호적진통효과，술후각시간점적VAS평분급술후48 h환자자공정맥진통빙안압차수비교차이균무통계학의의（ P균>0.05）；B조악심구토발생솔현저고우A조（P<0.05）。결론재폐암흉강경수술술후진통중，지좌신복합불비락분지독부반응경차진통량호。
Objective To compare the effects of dezocine combined with flurbiprofen axetil or tramadol in the postoperative analgesia of patients treated with thorascopic surgery. Methods Sixty patients scheduled for video-as-sisted thoracoscopic surgery were randomly divided into 2 groups. All the patients received an intravenous load dose of dezocine 0. 1-0. 15 mg·kg-1 and tropisetron 6 mg in the 30 min after surgery. Patient controlled analgesia pump (2 mL·h-1 )was performed in all the patients. The formula of patient controlled analgesia in the group A was dezocine 0. 5 mg·kg-1 combined with flurbiprofen axetil 3 mg·kg-1 and tropisetron 6 mg;that of the B group was dezocine 0. 5 mg·kg-1 combined with tramadol 10 mg·kg-1 . VAS scores were recorded in the 2,4,12,24 and 48 h after the surgery. Automatic frequency and toxicities of patient controlled analgesia were also recorded in the 48 h after the surgery. Results All the patients of the two groups got favourable analgesia. No significant difference was observed between the two groups in the VAS scores at all the observed points and the automatic frequency in the 48 h after the surgery. The nausea and vomiting rate significant higher in the group B was than that in the group A. Conclusion Dezocine combined with flurbiprofen axetil is safe and effect in the postoperative analgesia of patients treated with thorascopic surgery.
