山东医学高等专科学校学报
山東醫學高等專科學校學報
산동의학고등전과학교학보
JOURNAL OF SHANDONG MEDICAL COLLEGE
2014年
6期
423-425,426
,共4页
ER%PR%C-erbB-2%乳腺癌%复发%转移
ER%PR%C-erbB-2%乳腺癌%複髮%轉移
ER%PR%C-erbB-2%유선암%복발%전이
ER%PR%C-erbB-2%Brest cancer%Recur-rence%Metastasis
目的：研究雌激素受体、孕激素受体及C‐erbB‐2受体在乳腺癌原发灶和复发转移病灶中的表达差异及其临床意义。方法收集45例经病理确诊的复发乳腺癌患者原发灶组织标本及复发术后组织标本，利用免疫组化法检测ER、PR及C‐erbB‐2在乳腺癌原发灶和复发转移灶中的表达。结果 E R总的变化率为64．4％（ P ＜0．05），其中46．7％的患者E R由阳性转为阴性，另外17．8％的患者ER由阴性转为阳性。PR的总变化率为18．2％（ P ＜0．05），由原发灶阳性变为转移灶阴性者占26．7％，另外17．8％患者由阴性转为阳性。C‐er bB‐2的变化没有统计学差异。结论结果表明在乳腺癌原发灶和复发转移灶之间确实存在着激素受体表达差异的变化，建议尽可能对复发转移乳腺癌病灶重新测定激素受体表达情况，以规范患者诊治，延长患者生存期。
目的：研究雌激素受體、孕激素受體及C‐erbB‐2受體在乳腺癌原髮竈和複髮轉移病竈中的錶達差異及其臨床意義。方法收集45例經病理確診的複髮乳腺癌患者原髮竈組織標本及複髮術後組織標本，利用免疫組化法檢測ER、PR及C‐erbB‐2在乳腺癌原髮竈和複髮轉移竈中的錶達。結果 E R總的變化率為64．4％（ P ＜0．05），其中46．7％的患者E R由暘性轉為陰性，另外17．8％的患者ER由陰性轉為暘性。PR的總變化率為18．2％（ P ＜0．05），由原髮竈暘性變為轉移竈陰性者佔26．7％，另外17．8％患者由陰性轉為暘性。C‐er bB‐2的變化沒有統計學差異。結論結果錶明在乳腺癌原髮竈和複髮轉移竈之間確實存在著激素受體錶達差異的變化，建議儘可能對複髮轉移乳腺癌病竈重新測定激素受體錶達情況，以規範患者診治，延長患者生存期。
목적：연구자격소수체、잉격소수체급C‐erbB‐2수체재유선암원발조화복발전이병조중적표체차이급기림상의의。방법수집45례경병리학진적복발유선암환자원발조조직표본급복발술후조직표본，이용면역조화법검측ER、PR급C‐erbB‐2재유선암원발조화복발전이조중적표체。결과 E R총적변화솔위64．4％（ P ＜0．05），기중46．7％적환자E R유양성전위음성，령외17．8％적환자ER유음성전위양성。PR적총변화솔위18．2％（ P ＜0．05），유원발조양성변위전이조음성자점26．7％，령외17．8％환자유음성전위양성。C‐er bB‐2적변화몰유통계학차이。결론결과표명재유선암원발조화복발전이조지간학실존재착격소수체표체차이적변화，건의진가능대복발전이유선암병조중신측정격소수체표체정황，이규범환자진치，연장환자생존기。
Objective To study the differences in the expressions of estrogen receptor (ER) ,progesterone receptor (PR) and C‐erbB‐2 receptor between primary lesions and recurrent and metastatic lesions in cases of breast cancer and its clinical significance .Methods The expressions of ER ,PR and C‐erbB‐2 receptor between primary lesions and recur‐rent and metastatic lesions in 45 cases of pathologically confirmed breast cancer were detected through immunohisto‐chemical assaying method .Results The total ER vibration rate was 64 .4% ( P<0 .05) ,and 46 .7% of the patients had their ER converted from positive status to negative status ,while 17 .8% of patients had their ER converted from negative status to positive status .The total PR vibration rate was18 .2% ( P<0 .05) ,and 26 .7% of the patients had their PR converted from positive status to negative status ,while 17 .8% of patients had their PR converted from nega‐tive status to positive status .No statistical difference was found in C‐erbB‐2 status .Conclusion There exist changes in the expressions of hormone receptors between primary lesions and recurrent and metastatic lesions ,and it is necessary to reevaluate the status of hormone receptors in recurrent breast cancers to standardize the diagnosis and treatment and to prolong patients’ survival time .
