山东医学高等专科学校学报
山東醫學高等專科學校學報
산동의학고등전과학교학보
JOURNAL OF SHANDONG MEDICAL COLLEGE
2014年
6期
421-422
,共2页
盐酸莫西沙星%微丸胶囊%固体分散体%溶出度
鹽痠莫西沙星%微汍膠囊%固體分散體%溶齣度
염산막서사성%미환효낭%고체분산체%용출도
Moxifloxacin hydrochloride%Pellet capsules%Solid dispersion%Dissolution
目的：制备盐酸莫西沙星微丸胶囊研究其溶出行为。方法采用挤出滚圆法制备载药丸心，溶剂法制备盐酸莫西沙星固体分散体，离心造粒法制备成品微丸。考察微丸的粉体学性质及微丸胶囊的溶出行为。结果本方法制备的盐酸莫西沙星微丸胶囊质量好，溶出迅速。结论该方法制备盐酸莫西沙星微丸胶囊可行。
目的：製備鹽痠莫西沙星微汍膠囊研究其溶齣行為。方法採用擠齣滾圓法製備載藥汍心，溶劑法製備鹽痠莫西沙星固體分散體，離心造粒法製備成品微汍。攷察微汍的粉體學性質及微汍膠囊的溶齣行為。結果本方法製備的鹽痠莫西沙星微汍膠囊質量好，溶齣迅速。結論該方法製備鹽痠莫西沙星微汍膠囊可行。
목적：제비염산막서사성미환효낭연구기용출행위。방법채용제출곤원법제비재약환심，용제법제비염산막서사성고체분산체，리심조립법제비성품미환。고찰미환적분체학성질급미환효낭적용출행위。결과본방법제비적염산막서사성미환효낭질량호，용출신속。결론해방법제비염산막서사성미환효낭가행。
Objective To prepare Moxifloxacin hydrochloride pellet capsules and study its dissolution . Methods Pellet cores were prepared by extrusion spheronization equipment ,solid dispersion by dissolution method and pellets by centrifugation pelletizing .T he micromeritic properties and in vitro dissolution of the pellet capsules were investigated .Results The quality of the pellet capsules was good and the dissolution was very quick .Conclusion The preparation methods is feasible .
