CAJ | 학술논문

利用长期大鼠高烟酰胺喂养模型，观察烟酰胺超载对血浆内甲基化反应指标的影响。结果发现，高烟酰胺摄入将伴随高甲基供体消耗，并引起血中甜菜碱水平明显降低，直接证明过量烟酰胺会导致甲基库耗竭。这表明过量的烟酰胺可能通过甲基耗竭诱导氧化性线粒体和 DNA 损伤及 DNA 甲基化样式的改变。
이용장기대서고연선알위양모형，관찰연선알초재대혈장내갑기화반응지표적영향。결과발현，고연선알섭입장반수고갑기공체소모，병인기혈중첨채감수평명현강저，직접증명과량연선알회도치갑기고모갈。저표명과량적연선알가능통과갑기모갈유도양화성선립체화 DNA 손상급 DNA 갑기화양식적개변。
Long-term high nicotinamide feeding test was performed to investigate the effect of excess nicotinamide on plasma methylation reaction levels. The results shown high nicotinamide intake may lead to a depletion of labile methyl groups. Nicotinamide overload significantly lower plasma betaine levels which suggested the deletion of methyl groups. Therefore, the present study demonstrated that excess nicotinamide may trigger oxidative damage and abnormal DNA methylation patterns due to promote the generation of ROS and its depletion of the methyl donor pool.