CAJ | 학술논문

目的：探讨联合检测血清中的CEA、AFP、CA724、CA199多项肿瘤标志物在消化道肿瘤诊断中的价值。方法采用电化学发光技术对200例消化道恶性肿瘤患者及200例相应良性疾病患者进行CEA、AFP、CA724、CA199测定。结果恶性肿瘤组的四种标志物的表达均高于良性疾病组，差异具有统计学意义；四种标志物联合检测阳性率大于单个指标检测阳性率，差异有统计学意义。结论 CEA 、AFP 、CA724、CA199对于消化道肿瘤的诊断具有重要的临床意义，联合检测可提高诊断消化道恶性肿瘤的阳性率。
목적：탐토연합검측혈청중적CEA、AFP、CA724、CA199다항종류표지물재소화도종류진단중적개치。방법채용전화학발광기술대200례소화도악성종류환자급200례상응량성질병환자진행CEA、AFP、CA724、CA199측정。결과악성종류조적사충표지물적표체균고우량성질병조，차이구유통계학의의；사충표지물연합검측양성솔대우단개지표검측양성솔，차이유통계학의의。결론 CEA 、AFP 、CA724、CA199대우소화도종류적진단구유중요적림상의의，연합검측가제고진단소화도악성종류적양성솔。
Objective To investigate diagnostic value of combined detection of multiple tumor markers CEA ,AFP ,CA724 , and CA199 in digestive tract malignancies .Methods Serum CEA ,AFP ,CA724 ,and CA199 of 200patients with digestive tract malignancies and 200 patients with benign digestive tract diseases were measured by electrochemiluminescence technology .Re- sults Four markers of the group with malignancy were higher than the group with benign tumor ,and the differences among them were significant .Positive rate of combined detection of four markers was greater than any individual one ,while significant differences were statistically .Conclusions CEA ,AFP ,CA724 ,and CA199 play important role in clinical detection and diagnosis of digestive tract tumors ,and positive rate of digestive tract cancer can be improved by the combined detection of these four markers .