CAJ | 학술논문

目的：研究CD90在大鼠肝癌发生过程中的表达及意义。方法免疫组织化学技术检测二乙基亚硝胺（DEN ）诱发的大鼠肝癌发生过程中CD90的动态表达。结果 DEN诱发肝细胞癌诱癌率为100％，大鼠肝癌癌变过程大致分为肝细胞损伤期、增生硬化期和癌变期3个时期。在正常大鼠肝组织，无CD90阳性细胞表达。随着肝癌的发生发展，CD90阳性表达细胞逐渐增多，主要分布于汇管区周围。进入癌变期，CD90阳性细胞数量增多，弥漫分布。结论 CD90在大鼠肝癌发生过程中的表达逐渐增高，认为其与肝癌的发生发展密切有关。
목적：연구CD90재대서간암발생과정중적표체급의의。방법면역조직화학기술검측이을기아초알（DEN ）유발적대서간암발생과정중CD90적동태표체。결과 DEN유발간세포암유암솔위100％，대서간암암변과정대치분위간세포손상기、증생경화기화암변기3개시기。재정상대서간조직，무CD90양성세포표체。수착간암적발생발전，CD90양성표체세포축점증다，주요분포우회관구주위。진입암변기，CD90양성세포수량증다，미만분포。결론 CD90재대서간암발생과정중적표체축점증고，인위기여간암적발생발전밀절유관。
Objective To investigate the expression and significance of CD90 during hepatocarcinogenesis in rats .Methods Immunohistochemistry technique was used to investigate the dynamic expression of CD90 during hepatocarcinogenesis induced by diethylnitrosamine (DEN) in rats .Results 100% hepatocellular carcinoma was induced by DEN .The procession of hepato- carcinogenesis in this model included three stages ,such as hepatic toxin lesion ,hepatic proliferation/cirrhosis and hepatic carci- nogenesis .There was no CD90 expression in normal liver cell .An increasing tendency of CD90 expression was shown from he- patic toxin lesion to hepatic proliferation/cirrhosis stage located mainly in periportal area .A large number of CD90 positive cells was shown in cancerous cells at terminal cancer stage .Conclusion The increasing expression of CD90 in hepatocarcinogenesis is related closely to the occurrence and development of hepatoma .