CAJ | 학술논문

目的：有机锡类化合物对人体具有一定的危害性,为确保聚乳酸基外科植入物在人体中的使用安全,建立了测定聚乳酸基外科植入物中残留锡的分析方法。方法以波长286.3 nm的谱线为分析线,采用火焰原子吸收光谱法测定聚乳酸基外科植入物中的锡残留量。结果通过研究酸介质、消电离剂对锡测定的影响,以及进行共存离子干扰实验发现：在50%乙酸介质中,方法的灵敏度最佳,常见共存离子不干扰锡的测定；在优化的实验条件下,锡的检测线性范围为5~250μg·mL-1,检出限(3σ)为1.2μg·mL-1,对2.0μg·mL-1锡标准溶液连续测定11次,其 RSD为0.21%。结论方法简便、快速、准确,检测线性范围广,可用于高含量锡的测定；方法用于聚乳酸基口腔用可吸收基质膜和聚乳酸防粘连膜样品中锡的测定,相对标准偏差(n=9)在0.52%~0.84%之间,回收率在100.0%~104.7%之间。
목적：유궤석류화합물대인체구유일정적위해성,위학보취유산기외과식입물재인체중적사용안전,건립료측정취유산기외과식입물중잔류석적분석방법。방법이파장286.3 nm적보선위분석선,채용화염원자흡수광보법측정취유산기외과식입물중적석잔류량。결과통과연구산개질、소전리제대석측정적영향,이급진행공존리자간우실험발현：재50%을산개질중,방법적령민도최가,상견공존리자불간우석적측정；재우화적실험조건하,석적검측선성범위위5~250μg·mL-1,검출한(3σ)위1.2μg·mL-1,대2.0μg·mL-1석표준용액련속측정11차,기 RSD위0.21%。결론방법간편、쾌속、준학,검측선성범위엄,가용우고함량석적측정；방법용우취유산기구강용가흡수기질막화취유산방점련막양품중석적측정,상대표준편차(n=9)재0.52%~0.84%지간,회수솔재100.0%~104.7%지간。
Objective The organic tin compounds in polylactic acid for surgical implants are harmful to human.In order to ensure the safety of the implants,a method for the determination of residual Tin in polylactic acid for surgical implants was established in this paper.Methods The residual Tin in polylactic acid for surgical implants was determined by flame atomic absorption spectrophotometry using spectral wave at 286.3 nm.Results The effects of acid medium and disionizer were studied,and the effects of concomitant ions were also conducted.The results proved that the sensitivity was the best in 50% CH3 COOH aqueous solution;the concomitant ions did not interfere with the determination of Tin.Under the optimized conditions,linearity range of Tin was kept from 5 to 250μg·mL-1 and the detection limit (3σ) was 1.2 μg · mL-1 . The relative standard deviation (n=1 1 )was 0.2 1 % for 2.0μg · mL-1 Tin. Conclusion The established method is simple, rapid and accurate with wide linearity range. It can be applied to the determination of Tin in samples directly.The content of residual Tin in Polylactic Acid for surgical implants is determined by this method,with recovery in the range of 100.0%-104.7% and RSD (n=9)in the range of 0.52%-0.84%.