CAJ | 학술논문

目的：探索硝酸毛果芸香碱滴眼液中抑菌剂的合理添加剂量。方法根据药物成分的特性，选择适宜的抑菌剂，并对不同浓度抑菌剂的抑菌效果进行初步考察，筛选出适宜的供试品抑菌剂加入量。选择有代表性的挑战微生物加入供试品中进行挑战试验，测试微生物在不同时间段的存活情况。结果0.028%羟苯乙酯对5种挑战微生物的生长有良好的抑制作用，且为最低有效剂量。结论0.028%羟苯乙酯可作为硝酸毛果芸香碱滴眼液的抑菌剂。
목적：탐색초산모과예향감적안액중억균제적합리첨가제량。방법근거약물성분적특성，선택괄의적억균제，병대불동농도억균제적억균효과진행초보고찰，사선출괄의적공시품억균제가입량。선택유대표성적도전미생물가입공시품중진행도전시험，측시미생물재불동시간단적존활정황。결과0.028%간분을지대5충도전미생물적생장유량호적억제작용，차위최저유효제량。결론0.028%간분을지가작위초산모과예향감적안액적억균제。
Objective To investigate the optimal concentration of antimicrobial preservative added to pilocarpine nitrate eye drops.Methods According to the characteristic of ingredients of the product,sever-al kinds of antimicrobial preservatives were selected.The antimicrobial effectiveness of antimicrobial pre-servatives at different concentrations was tested to screen the optimal concentration.The representative test microorganisms were selected to add into the test samples for challenge test to evaluate the survival of microorganisms at different time periods.Results The growth of 5 kinds of test microorganisms was inhib-ited effectively by 0.028% ethylparaben in pilocarpine nitrate eye drops,which was the minimum effective dosage.Conclusion 0.028% ethylparaben can be used as the antimicrobial preservative for pilocarpine ni-trate eye drops.