CAJ | 학술논문

目的：通过对非选择性单囊胚移植研究，探讨选择性单囊胚移植的临床价值以及内细胞团（ICM）、滋养外胚层（TE）在囊胚发育潜能中的作用。方法选择该中心非选择性单囊胚移植276周期，比较优质单囊胚与非优质单囊胚妊娠率、早期流产率；比较不同ICM和TE妊娠率、早期流产率。结果优质单囊胚移植临床妊娠率较非优质单囊胚临床妊娠率显著增高（ P＜0．05）；ICM A组的临床妊娠率较ICM C组的妊娠率显著增高（ P＜0．05）；TE A组的临床妊娠率较TE B组及TE C组显著增高（ P＜0．05）；各组早期流产率差异无统计学意义；多胎妊娠率为1．16％。结论单囊胚移植多胎率极低；优质单囊胚移植比非优质单囊胚移植可以获得较高临床妊娠率；CC级的囊胚仍有一定的妊娠率，在无其他可移植胚胎的情况下，经充分知情同意，可考虑移植CC级囊胚。
목적：통과대비선택성단낭배이식연구，탐토선택성단낭배이식적림상개치이급내세포단（ICM）、자양외배층（TE）재낭배발육잠능중적작용。방법선택해중심비선택성단낭배이식276주기，비교우질단낭배여비우질단낭배임신솔、조기유산솔；비교불동ICM화TE임신솔、조기유산솔。결과우질단낭배이식림상임신솔교비우질단낭배림상임신솔현저증고（ P＜0．05）；ICM A조적림상임신솔교ICM C조적임신솔현저증고（ P＜0．05）；TE A조적림상임신솔교TE B조급TE C조현저증고（ P＜0．05）；각조조기유산솔차이무통계학의의；다태임신솔위1．16％。결론단낭배이식다태솔겁저；우질단낭배이식비비우질단낭배이식가이획득교고림상임신솔；CC급적낭배잉유일정적임신솔，재무기타가이식배태적정황하，경충분지정동의，가고필이식CC급낭배。
Objective To investigate the clinical value of selective single blastocyst transfer , and effect of blastocyst developmental potential of the inner cell mass (ICM) and trophectoderm(TE) by non-selective single blas-tocyst transfer study .Methods Two hundreds and seventy-six cycles of non-selective single blastocyst transfer in the center were selected and the rate of pregnancy and the early abortion rate of high -quality single blastocyst were com-pared with non-quality single blastocyst ,and the rate of pregnancy and the early abortion rate in different levels of ICM and TE were compared .Results The clinical pregnancy rate of quality single blastocyst transfer was significantly higher than that of non-quality single blastocyst transfer ( P<0.05 );the clinical pregnancy rate of ICM for A was sig-nificantly higher than that of ICM for C ( P<0.05 ); the clinical pregnancy rate of TE for A was significantly higher than that of the TE for B or C ( P<0.05 ); the early abortion rate between the groups was not significant; Multiple pregnancy rate was 1.16%.Conclusion Multiple birth rate of single blastocyst transfer is very low; Quality single blastocyst transfer can get a higher clinical pregnancy rate than non-quality single blastocyst transfer;CC can obtain a low pregnancy rate , so in no other case of embryos , CC blastocyst can be transferd after the fully informed consent .