CAJ | 학술논문

以水凝胶钛网电极为基底的生物电极，通过在水凝胶中添加聚吡咯（PPy）、碳纳米管（SWNTs）和神经生长因子（NGF）形成不同的杂化水凝胶修饰电极，研究不同杂化水凝胶修饰生物电极的力学性能、电化学活性以及对细胞分化生长情况的影响。力学测试表明 SWNTs 和 PPy 能够显著提高水凝胶的压缩模量；循环伏安（CV）曲线表明 SWNTs 和 PPy 能提高杂化水凝胶修饰电极的电化学活性；细胞形貌观察发现 NGF 能够促进细胞分化，SWNTs 对细胞分化有增强作用，PPy 可以提高细胞的黏附并有利于释放 NGF，以促进细胞的生长与分化。
이수응효태망전겁위기저적생물전겁，통과재수응효중첨가취필각（PPy）、탄납미관（SWNTs）화신경생장인자（NGF）형성불동적잡화수응효수식전겁，연구불동잡화수응효수식생물전겁적역학성능、전화학활성이급대세포분화생장정황적영향。역학측시표명 SWNTs 화 PPy 능구현저제고수응효적압축모량；순배복안（CV）곡선표명 SWNTs 화 PPy 능제고잡화수응효수식전겁적전화학활성；세포형모관찰발현 NGF 능구촉진세포분화，SWNTs 대세포분화유증강작용，PPy 가이제고세포적점부병유리우석방 NGF，이촉진세포적생장여분화。
Titanium mesh electrode was modified with hybrid hydrogels composed of a conducting polymer of polypyrrole (PPy), single-walled carbon nanotubes (SWNTs),nerve growth factor (NGF)and a polymeric hydrogel of poly(ethylene glycol)diacry-late-polyacrylamide (PEGDA-PAAm).Mechanical properties and electrochemical performance as well as its effect on neuron growth were investigated.The results show that the incorporation of SWNTs and PPy dramatically enhances the compression modulus of the hydrogel.Meanwhile,the incorporated SWNTs and PPy greatly improve the electrochemical performance of the hybrid hydrogels,demonstrated by the cyclic voltammetry (CV)measurements.Observation of cell morphology indicates that NGF can enable the differentiation of the cells while SWNTs can help the enhancement.More importantly,PPy is favorable for neuron attachment and the release of NGF,which in turn promotes the growth and differentiation of the neural cells.