CAJ | 학술논문

全球恶性肿瘤的发病率和死亡率在不断升高，危害愈来愈大，引起全社会的广泛重视。现在多数治疗如手术、放疗、化疗由于有一定副作用都会给患者机体带来相当负担，所以要充分衡量增加一种治疗可能给患者带来的得与失。光动力治疗作为一种新型的肿瘤治疗技术，以其独特的靶向性、无耐药性等，引起越来越多学者的关注。研究表明，光动力杀伤肿瘤细胞是由多种机制介导的，除了已知的坏死和凋亡机制外，光动力诱导产生的炎性反应也能够间接有利于肿瘤细胞的清除。缺氧诱导因子1α（ HIF?1α）是具有转录活性的核蛋白，具有相当广泛的靶基因谱（如缺氧适应、炎症发展及肿瘤生长），其中所包括的血管内皮生长因子是最重要的促进血管化的基因之一。本文就近年HIF?1α在光动力治疗肿瘤细胞中的研究进展作一综述。
전구악성종류적발병솔화사망솔재불단승고，위해유래유대，인기전사회적엄범중시。현재다수치료여수술、방료、화료유우유일정부작용도회급환자궤체대래상당부담，소이요충분형량증가일충치료가능급환자대래적득여실。광동력치료작위일충신형적종류치료기술，이기독특적파향성、무내약성등，인기월래월다학자적관주。연구표명，광동력살상종류세포시유다충궤제개도적，제료이지적배사화조망궤제외，광동력유도산생적염성반응야능구간접유리우종류세포적청제。결양유도인자1α（ HIF?1α）시구유전록활성적핵단백，구유상당엄범적파기인보（여결양괄응、염증발전급종류생장），기중소포괄적혈관내피생장인자시최중요적촉진혈관화적기인지일。본문취근년HIF?1α재광동력치료종류세포중적연구진전작일종술。
Malignant tumors have become the leading cause of human death. Conventional anticancer treatment modalities, such as surgery, radiation and chemotherapy, are often deleterious to the patient due to the numerous associated side effects. Photody?namic therapy( PDT) as a new approach available to cancer therapy, with its unique targeting and non?drug resistance, caused more and more attention of scholars. Previous studies have shown that PDT destructed tumor by a variety of mechanisms. In addition to the known mechanism of necrosis and apoptosis, inflammatory reaction after PDT can also indirectly help the removal of tumor cells. Hy?poxia?inducible factor?1alpha( HIF?1α) is a nucleoprotein with transcriptional activity, possessing a wide spectrum of target genes( such as hypoxia adaptation, inflammation development and tumor growth) , which include vascular endothelial growth factor( VEGF) , one of the most important genes in promoting vascularization. In this review, we discuss the role of HIF?1α in the PDT of tumor cells.