CAJ | 학술논문

目的：探讨广西地区EBV感染与恶性淋巴瘤病理类型及发病的相关性。方法采用原位杂交技术检测81例口腔颌面颈部淋巴瘤的肿瘤组织中EBV编码的RNA(EBER),并分析其临床病理特征。结果(1)EBER总阳性率为44．4%,霍奇金淋巴瘤占检出率的40%,非霍奇金淋巴瘤占检出率的45．1%,不同细胞来源的非霍奇金淋巴瘤依次占检出率的75%( T细胞淋巴瘤)、87．5%( NK/T细胞淋巴瘤)、2．9%( B细胞淋巴瘤),T细胞、NK/T细胞非霍奇金淋巴瘤EBER阳性率比B细胞非霍奇金淋巴瘤高,差异有统计学意义(P<0．05)。(2)淋巴结内、外淋巴瘤EBER阳性率分别为17．9%、58．5%,二者比较差异有显著性(P<0．05)。(3)50岁以上淋巴瘤患者EBER检出率(36．2%)低于50岁以下患者检出率(55．9%),差异无显著性(P>0．05)。结论广西地区口腔颌面颈部淋巴瘤与EBV感染相关,其中以发生在淋巴结外弥散淋巴组织的NK/T细胞淋巴瘤最为显著。
목적：탐토엄서지구EBV감염여악성림파류병리류형급발병적상관성。방법채용원위잡교기술검측81례구강합면경부림파류적종류조직중EBV편마적RNA(EBER),병분석기림상병리특정。결과(1)EBER총양성솔위44．4%,곽기금림파류점검출솔적40%,비곽기금림파류점검출솔적45．1%,불동세포래원적비곽기금림파류의차점검출솔적75%( T세포림파류)、87．5%( NK/T세포림파류)、2．9%( B세포림파류),T세포、NK/T세포비곽기금림파류EBER양성솔비B세포비곽기금림파류고,차이유통계학의의(P<0．05)。(2)림파결내、외림파류EBER양성솔분별위17．9%、58．5%,이자비교차이유현저성(P<0．05)。(3)50세이상림파류환자EBER검출솔(36．2%)저우50세이하환자검출솔(55．9%),차이무현저성(P>0．05)。결론엄서지구구강합면경부림파류여EBV감염상관,기중이발생재림파결외미산림파조직적NK/T세포림파류최위현저。
Purpose To investigate the relation of Epstein-Barr virus ( EBV) infections and malignant lymphoma. Methods EBV-co-ded RNA ( EBER) was detected by in situ hybridization in tumor tissue of 81 cases of malignant lymphoma in oral, maxillofacial and neck regions, with analysis of the clinical pathological features. Results The detection frequencies of EBER was 44. 44%. The posi-tive detection of EBER in Hodgkin′s lymphomas was 40% and that in non-Hodgkin lymphomas was 45. 1%, including 75% in T cell lymphomas, 87. 5% in NK/T cell lymphomas and 2. 9% in B-cell lymphoma. The positive rates of EBER in T cell lymphomas and NK/T cell lymphomas were significantly higher than that in B-cell lymphoma (P<0. 05). There was a significant difference in the pos-itive rates of EBER between intra-nodal ( 17. 9%) and extra-nodal ( 58. 5%) lymphomas ( P<0. 05 ) . But there was no significant difference the positive rates of EBER between in lymphoma patients over 50 years of age and under the age of 50 patients (55. 9%) (P>0. 05). Conclusion Oral and maxillofacial and neck lymphoma is closely associated with EBV infection in Guangxi region, espe-cially, in which NK/T cell lymphoma most typically occurs in extra-nodal diffuse lymphoid tissues.