CAJ | 학술논문

目的：探讨桥本甲状腺炎伴不典型细胞与甲状腺乳头状癌( papillary thyroid carcinoma,PTC)的鉴别诊断。方法收集桥本甲状腺炎153例,分为桥本甲状腺炎伴不典型细胞组(32例)、桥本甲状腺炎伴PTC组(49例)、桥本甲状腺炎对照组(72例)。采用HE及免疫组化法分析各组间的差异。结果桥本甲状腺炎伴不典型细胞与PTC有形态学差异。伴PTC组Galec-tin-3、CK19阳性率高于伴不典型细胞组,CD56阳性率低于伴不典型细胞组,差异均有统计学意义。 Ki-67阳性率在伴不典型细胞组与伴PTC组之间差异无显著性,但与对照组之间差异有统计学意义。结论以组织形态学特征为基础,联合应用CD56、CK19、Galectin-3、Ki-67可有效鉴别桥本甲状腺炎伴不典型细胞与PTC。
목적：탐토교본갑상선염반불전형세포여갑상선유두상암( papillary thyroid carcinoma,PTC)적감별진단。방법수집교본갑상선염153례,분위교본갑상선염반불전형세포조(32례)、교본갑상선염반PTC조(49례)、교본갑상선염대조조(72례)。채용HE급면역조화법분석각조간적차이。결과교본갑상선염반불전형세포여PTC유형태학차이。반PTC조Galec-tin-3、CK19양성솔고우반불전형세포조,CD56양성솔저우반불전형세포조,차이균유통계학의의。 Ki-67양성솔재반불전형세포조여반PTC조지간차이무현저성,단여대조조지간차이유통계학의의。결론이조직형태학특정위기출,연합응용CD56、CK19、Galectin-3、Ki-67가유효감별교본갑상선염반불전형세포여PTC。
Purpose To analyze differential diagnosis between Hashimoto thyroiditis of atypical cell clusters ( ACC) and papillary thy-roid carcinoma (PTC). Methods 153 cases of Hashimoto thyroiditis (HT) were collected and divided into 3 groups:PTC group (49 cases), ACC group (32 cases), and HT as control group (72 cases). Morphology observations were done. CD56, CK19, galectin-3 and Ki-67 were detected by immunohistochemistry. Results Morphologic differences were observed among the groups. PTC showed milder positive expression of CK19 and galectin-3, and weaker positive expression of CD56 than that of ACC. Ki-67 index in ACC and PTC was lower than that of HT. Conclusions Morphological characteristics combined with CD56, CK19, Galectin-3 and Ki-67 evalu-ations could be valuable in the differential diagnosis between PTC and ACC.