CAJ | 학술논문

目的：探讨Periostin、VEGF蛋白在食管鳞状细胞癌组织中的表达及意义。方法采用免疫组化SP法检测130例食管鳞状细胞癌组织及癌旁正常食管黏膜组织中Periostin、VEGF蛋白的表达。结果食管鳞状细胞癌组织中Periostin和VEGF的阳性率明显高于正常食管黏膜组织(P<0．05)。 Periostin表达与食管鳞状细胞癌浸润深度、淋巴结转移有显著相关性(P<0．05)。 VEGF表达与食管鳞状细胞癌分化程度、浸润深度和淋巴结转移有显著相关性(P<0．05)。 Periostin与VEGF表达呈正相关(P<0．05),66例食管鳞状细胞癌患者获得临床随访资料,随访时间1~48个月,Kaplan-Meier生存曲线分析显示,Peri-ostin阳性组患者的生存率明显低于 Periostin阴性组( P<0．05), VEGF阳性组患者的生存率明显低于 VEGF 阴性组( P <0．05)。结论 Periostin与VEGF表达密切相关,联合检测Periostin、VEGF可作为判定食管鳞状细胞癌侵袭、转移能力的客观指标,对食管鳞状细胞癌的预后判断具有重要意义。
목적：탐토Periostin、VEGF단백재식관린상세포암조직중적표체급의의。방법채용면역조화SP법검측130례식관린상세포암조직급암방정상식관점막조직중Periostin、VEGF단백적표체。결과식관린상세포암조직중Periostin화VEGF적양성솔명현고우정상식관점막조직(P<0．05)。 Periostin표체여식관린상세포암침윤심도、림파결전이유현저상관성(P<0．05)。 VEGF표체여식관린상세포암분화정도、침윤심도화림파결전이유현저상관성(P<0．05)。 Periostin여VEGF표체정정상관(P<0．05),66례식관린상세포암환자획득림상수방자료,수방시간1~48개월,Kaplan-Meier생존곡선분석현시,Peri-ostin양성조환자적생존솔명현저우 Periostin음성조( P<0．05), VEGF양성조환자적생존솔명현저우 VEGF 음성조( P <0．05)。결론 Periostin여VEGF표체밀절상관,연합검측Periostin、VEGF가작위판정식관린상세포암침습、전이능력적객관지표,대식관린상세포암적예후판단구유중요의의。
Purpose To investigate the expression of Periostin and VEGF protein in esophageal squamous cell carcinoma tissue and their significance. Methods Immunohistochemical staining (SP method) was used to detect Periostin and VEGF expression in 130 cases of esophageal squamous cell carcinoma and 130 cases of normal esophageal mucosa tissues. Results There was a significantly difference between esophageal squamous cell carcinoma and normal esophageal mucoma ( P<0. 05 ) . The expression of Periostin was related to the depth of invasion and the metastasis of lymph node (P<0. 05). A dramatic correlation has been found in the expression of VEGF to the degrees of differentiation, the depth of invasion and the metastasis of lymph node (P<0. 05). The expression of Peri-ostin was also positively correlated with the expression of VEGF (P<0. 05). Follow-up data was available in 66 cases with a range of 1 to 48 months. Kaplan-Meier survival curve showed survival rate of Periostin-positive group was significantly lower than that of Perios-tin-negative group (P<0. 05). The survival rate of VEGF-positive group was significantly lower than that of VEGF-negative group (P<0. 05). Conclusion The expression of Periostin has a close relationship with VEGF in the carcinogenesis, combined detection of both Periostin and VEGF can become an objective target to evaluate Potentials of invasion and lymph node metastasis of esophageal squamous cell carcinoma, which has a great significance to the judgment of prognosis in esophageal squamous cell carcinoma.