CAJ | 학술논문

目的：探讨儿童Graves病合并系统性红斑狼疮(SLE)的临床特点及诊断。方法回顾性分析1例Graves病合并SLE患儿的临床资料。结果13岁女孩，以发热、抽搐为首发症状，经甲状腺功能、头颅磁共振、自身免疫性抗体、肾脏及甲状腺穿刺检查后诊断为SLE合并肾炎、Graves病、脑梗死、脑白质脱髓鞘。结论长期发热、抽搐患儿除了常见疾病外应考虑到自身免疫性疾病，确诊自身免疫性甲状腺疾病的患儿应查自身抗体排除SLE。
목적：탐토인동Graves병합병계통성홍반랑창(SLE)적림상특점급진단。방법회고성분석1례Graves병합병SLE환인적림상자료。결과13세녀해，이발열、추휵위수발증상，경갑상선공능、두로자공진、자신면역성항체、신장급갑상선천자검사후진단위SLE합병신염、Graves병、뇌경사、뇌백질탈수초。결론장기발열、추휵환인제료상견질병외응고필도자신면역성질병，학진자신면역성갑상선질병적환인응사자신항체배제SLE。
Objective To investigate the clinical characteristics, diagnosis and the differential diagnosis of Graves’ disease complicated with systemic lupus erythematosus (SLE) in children. Methods A child diagnosed of Graves’ disease complicated with SLE were reviewed. Results A 13-year-old girl, with fever and convulsions as the onset symptom, had the following examines performed:T3, T4, TSH, brain MRI, TPOAb, TGAb, anti-dsDNA, anti-smDNA, anti-ENA antibodies, antinuclear antibodies, renal and thyroid biopsies. SLE with lupus nephritis, Graves’ disease, cerebral infarction and cerebral white matter demyelination were diagnosed. Conclusions In addition to common diseases, autoimmune disease should also be considered for children with long-time fever and convulsions. Autoantibodies should be checked for children diagnosed of autoimmune thyroid disease.