CAJ | 학술논문

目的：探讨新生儿高促甲状腺素血症(HT)的临床转归。方法定期随访高促甲状腺激素(TSH)血症患儿，评估其生长发育指标和甲状腺功能及治疗效果。结果新生儿筛查血清TSH 5.6~10 mU/L的191例患儿随访至24个月；182例血TSH逐渐恢复正常，5例血TSH逐渐升高>10 mU/L，予以左甲状腺素钠治疗，4例随访2年后血TSH值仍波动在5.6~10 mU/L，继续随访中；血清TSH在10~20 mU/L的44例患儿，予以左甲状腺素钠治疗后38例血TSH值逐渐恢复正常；7例血TSH>20 mU/L患儿需持续左甲状腺素钠治疗。242例HT新生儿中共有18例持续服用左甲状腺素钠替代治疗2年，继续随访。结论大多数新生儿HT随年龄增长逐渐恢复正常，有少部分患儿出现甲状腺功能异常，应积极随访。
목적：탐토신생인고촉갑상선소혈증(HT)적림상전귀。방법정기수방고촉갑상선격소(TSH)혈증환인，평고기생장발육지표화갑상선공능급치료효과。결과신생인사사혈청TSH 5.6~10 mU/L적191례환인수방지24개월；182례혈TSH축점회복정상，5례혈TSH축점승고>10 mU/L，여이좌갑상선소납치료，4례수방2년후혈TSH치잉파동재5.6~10 mU/L，계속수방중；혈청TSH재10~20 mU/L적44례환인，여이좌갑상선소납치료후38례혈TSH치축점회복정상；7례혈TSH>20 mU/L환인수지속좌갑상선소납치료。242례HT신생인중공유18례지속복용좌갑상선소납체대치료2년，계속수방。결론대다수신생인HT수년령증장축점회복정상，유소부분환인출현갑상선공능이상，응적겁수방。
Objective To study the prognosis of neonatal hyperthyrotropinemia (HT). Methods Children with HT were followed up regularly to evaluate the growth index, thyroid function and effectiveness of treatment. Results One hundred and ninety-one neonates with serum TSH level of 5.6~10 mU/L at the screening were followed up until 24 months old. Serum TSH gradually returned to normal range in 182 cases. Serum TSH increased to be>10 mU/L in 5 cases who were treated with levothy-roxine sodium. Serum TSH lfuctuated between 5.6 and 10 mU/L in 4 cases who were continually followed up. Among 44 cases of serum TSH at 10~20mU/L, serum TSH gradually returned to normal range after levothyroxine sodium treatment in 38 cases;se-rum TSH increased to>20 mU/L in 7 cases for whom continuous treatment with levothyroxine sodium was required. In 242 cases of HT neonates, 18 cases had received continuous levothyroxine sodium replacement treatment for 2 years and were followed-up continuously. Conclusions Most of the newborns with HT recover within 2 years, while a few develop thyroid dysfunction and require follow-ups.