CAJ | 학술논문

目的：了解我院2010年～2013年呼吸科AECOPD住院病人痰标本分离病原菌的变迁及耐药趋势变化，指导临床合理使用抗菌药物。方法对2010年～2013年临床分离的756株病原菌进行细菌鉴定和药敏试验，并将结果进行回顾性研究比较、分析。结果2010年～2012年，革兰氏阴性菌分离率逐年增高，排名前4位的致病菌分别为铜绿假单胞菌、鲍曼不动杆菌、肺炎克雷伯菌和大肠埃希菌。4种细菌对常用的抗菌药物均有不同程度耐药，并对多数抗菌药物的耐药率呈升高趋势；而2013年，4种致病菌对常用抗菌药物耐药性有下降趋势。结论通过掌握病原菌的变迁及耐药性的变化趋势，指导临床合理用药，延缓细菌耐药。
목적：료해아원2010년～2013년호흡과AECOPD주원병인담표본분리병원균적변천급내약추세변화，지도림상합리사용항균약물。방법대2010년～2013년림상분리적756주병원균진행세균감정화약민시험，병장결과진행회고성연구비교、분석。결과2010년～2012년，혁란씨음성균분리솔축년증고，배명전4위적치병균분별위동록가단포균、포만불동간균、폐염극뢰백균화대장애희균。4충세균대상용적항균약물균유불동정도내약，병대다수항균약물적내약솔정승고추세；이2013년，4충치병균대상용항균약물내약성유하강추세。결론통과장악병원균적변천급내약성적변화추세，지도림상합리용약，연완세균내약。
ABSRACT: Objective To study the characteristics of etiology and drug resistance in patients with chronic obstructive pulmonary disease of acute exacerbation stage (AECOPD) so as to provide basis for the clinical treatment. Methods The sputum of AECOPD patients who enrolled the hospital from 2010 to 2013 was cultured. A total of 756 strains of bacteria were isolated, and the distribution of the pathogens and the drug resistance were retrospectively analyzed. Results The respiratory infection in patients with AECOPD was mainly due to the gram-negative bacterial. The most predominant pathogen isolated was Pseudomonas aeruginosa, followed by Acinetobacter baumannii, Klebsiella pneumoniae and Escherichia coli, which were resistant to common antibiotics, and the detection rate of drug resistant strains shows a upward trend from 2010 to 2012.Whereas there was a downward trend of drug resistant for that four pathogens in 2013. Conclusion It is necessary for the hospital to reasonably use antibiotics in accordance with the distribution of the pathogens and the drug resistance.