CAJ | 학술논문

目的：探讨慢性阻塞性肺疾病急性加重期给予氨溴索序贯治疗的临床效果。方法80例慢性阻塞性肺疾病急性加重期患者随机分为观察组和对照组，各40例。对照组给予常规治疗，观察组在常规治疗基础上给予氨溴索序贯治疗。观察两组患者治疗前和治疗后肺功能、C反应蛋白水平改变情况。结果观察组患者治疗前后的C反应蛋白水平降低值、一秒用力呼气容积(FEV1)、一秒用力呼气容积占用肺活量百分比(FEV1/FVC)升高值分别与对照组比较，差异有统计学意义(P<0.05)。观察组的总有效率高于对照组，差异有统计学意义(P<0.05)。结论氨溴索序贯治疗慢性阻塞性肺疾病急性加重期临床效果显著，值得借鉴。
목적：탐토만성조새성폐질병급성가중기급여안추색서관치료적림상효과。방법80례만성조새성폐질병급성가중기환자수궤분위관찰조화대조조，각40례。대조조급여상규치료，관찰조재상규치료기출상급여안추색서관치료。관찰량조환자치료전화치료후폐공능、C반응단백수평개변정황。결과관찰조환자치료전후적C반응단백수평강저치、일초용력호기용적(FEV1)、일초용력호기용적점용폐활량백분비(FEV1/FVC)승고치분별여대조조비교，차이유통계학의의(P<0.05)。관찰조적총유효솔고우대조조，차이유통계학의의(P<0.05)。결론안추색서관치료만성조새성폐질병급성가중기림상효과현저，치득차감。
Objective To explore the clinical effect of ambroxol sequential therapy in the treatment of acute exacerbation of chronic obstructive pulmonary disease. Methods A total of 80 patients with acute exacerbation of chronic obstructive pulmonary disease were randomly divided into observation group and control group, with 40 cases in each group. The control group was given routine treatment, while the observation group received additional ambroxol sequential therapy. The changes of the pulmonary function, and C-reactive protein were observed before and after treatment in the two groups. Results The decreased C-reactive protein level, and elevated levels of forced expiratory volume in 1 second (FEV1) and forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC) after treatment in the observation group were compared with those before and after treatment in the control group, and the difference was statistically significant (P<0.05). The total effective rate of the observation group was higher than that of the control group, and the difference had statistical significance (P<0.05). Conclusion Ambroxol sequential therapy has precise effect in the treatment of acute exacerbation of chronic obstructive pulmonary disease, and it is worthy of reference.