CAJ | 학술논문

目的：探讨新疆地区维吾尔族长寿老人载脂蛋白 E 基因多态性与血压的关系。方法以课题组1997—2003年多次流行病学调查所得维吾尔族长寿老人144例为研究对象，根据24 h 动态血压测量结果将其分为正常组（107例）和高血压组（37例）。应用聚合酶链反应_限制性片段长度多态性方法检测两组人群的载脂蛋白 E（ApoE）基因多态性。结果正常组与高血压组 ApoE 基因型分布间差异无统计学意义（p >0.05），两组中 E3/3占的比例均较其他基因型高，分别为76.6%（82/107）、64.9%（24/37）；两组 ApoE 等位基因分布间差异有统计学意义（ p <0.05），高血压组中携带 ApoE ε4频率（9.5%，7/37）高于正常组（2.3%，5/107）。不同 ApoE 表型的高血压患者的收缩压间差异有统计学意义（ p <0.05），带有ε4等位基因的高血压患者收缩压比带有其他等位基因者高。结论ApoE 基因多态性与新疆地区维吾尔族长寿老人收缩压相关。
목적：탐토신강지구유오이족장수노인재지단백 E 기인다태성여혈압적관계。방법이과제조1997—2003년다차류행병학조사소득유오이족장수노인144례위연구대상，근거24 h 동태혈압측량결과장기분위정상조（107례）화고혈압조（37례）。응용취합매련반응_한제성편단장도다태성방법검측량조인군적재지단백 E（ApoE）기인다태성。결과정상조여고혈압조 ApoE 기인형분포간차이무통계학의의（p >0.05），량조중 E3/3점적비례균교기타기인형고，분별위76.6%（82/107）、64.9%（24/37）；량조 ApoE 등위기인분포간차이유통계학의의（ p <0.05），고혈압조중휴대 ApoE ε4빈솔（9.5%，7/37）고우정상조（2.3%，5/107）。불동 ApoE 표형적고혈압환자적수축압간차이유통계학의의（ p <0.05），대유ε4등위기인적고혈압환자수축압비대유기타등위기인자고。결론ApoE 기인다태성여신강지구유오이족장수노인수축압상관。
[AbstraCt] ObjeCtive To study the relationship between apolipoprotein genotypes and blood pressure in longevous elderly Xinjiang Uighur people. Methods 144 longest Uighur elderly were recruited as the research subjects by several epidemiological investigations from 1997 to 2003 and divided into normotensive group(n = 107)and hypertension group(n =37)according to 24 _ hour ambulatory blood pressure monitoring results. Their apolipoprotein E(ApoE)genetic polymorphism was detected by polymerase chain reaction _ restriction fragment length polymorphism( PCR _ RFLP). Results The ApoE genotypes distribution had no statistically significance between normotensive group and hypertension group(p > 0. 05)and the E3 / 3 genotype had the highest frequeney:76. 6% (82 / 107),64. 9% (24 / 37)respectively;the allele distribution between the two group was significantly different( p < 0. 05),the prevalence of ε4 allele in hypertenion group(9. 5% ,7 / 37)was higher than that in normotensive group(2. 3% ,5 / 107). The differences of systolic blood pressures were significant between hypertension patients with different ApoE phenotypes(p < 0. 05)and individuals with the ε4 allele had a significantly higher systolic blood pressure than those carrying other alleles. ConClusion The polymorphism of ApoE gene and systolic blood pressure in longevous elderly in the Xinjiang Uighur people were correlated.