CAJ | 학술논문

目的：探讨氧气雾化吸入 N -乙酰半胱氨酸辅助治疗婴幼儿支气管肺炎的临床效果。方法选取2012年1月—2013年12月潍坊医学院附属潍坊市人民医院新生儿科收治的支气管肺炎患儿120例为研究对象，按照随机数字表法将其分为对照组与治疗组，各60例。所有患儿在抗感染、平喘及退热等药物治疗的基础上行氧气雾化吸入，治疗组氧气雾化吸入药物为 N -乙酰半胱氨酸雾化液，对照组为盐酸氨溴索。观察患儿体征（体温、气促、咳嗽、肺部啰音）及有无不良反应，并记录体征消失时间、住院时间。结果治疗组总有效率为95.0％（57/60），对照组总有效率为83.3％（50/60），差异有统计学意义（χ2＝4.227，P ﹤0.05）。治疗组患儿体温恢复正常时间、气促消失时间、咳嗽消失时间、肺部啰音消失时间和住院时间均短于对照组（P ﹤0.05）。治疗组不良反应发生率为1.7％（1/60），对照组不良反应发生率为5.0％（3/60），差异无统计学意义（χ2＝1.034，P ﹥0.05）。结论氧气雾化吸入 N -乙酰半胱氨酸辅助治疗婴幼儿支气管肺炎能提高治愈率，缩短病程，无明显不良反应，值得临床推广应用。
목적：탐토양기무화흡입 N -을선반광안산보조치료영유인지기관폐염적림상효과。방법선취2012년1월—2013년12월유방의학원부속유방시인민의원신생인과수치적지기관폐염환인120례위연구대상，안조수궤수자표법장기분위대조조여치료조，각60례。소유환인재항감염、평천급퇴열등약물치료적기출상행양기무화흡입，치료조양기무화흡입약물위 N -을선반광안산무화액，대조조위염산안추색。관찰환인체정（체온、기촉、해수、폐부라음）급유무불량반응，병기록체정소실시간、주원시간。결과치료조총유효솔위95.0％（57/60），대조조총유효솔위83.3％（50/60），차이유통계학의의（χ2＝4.227，P ﹤0.05）。치료조환인체온회복정상시간、기촉소실시간、해수소실시간、폐부라음소실시간화주원시간균단우대조조（P ﹤0.05）。치료조불량반응발생솔위1.7％（1/60），대조조불량반응발생솔위5.0％（3/60），차이무통계학의의（χ2＝1.034，P ﹥0.05）。결론양기무화흡입 N -을선반광안산보조치료영유인지기관폐염능제고치유솔，축단병정，무명현불량반응，치득림상추엄응용。
Objective To evaluate the therapeutic effect of aerosol inhalation of N - acetylcysteine and oxygen in treatment of infants with bronchopneumonia. Methods 120 infants with bronchopneumonia who were treated in Neonatal Department of Weifang Heopleˊs Hospital Affiliated to Weifang Medical University from January 2012 to December 2013 were selected as study subjects,cases were divided into treatment group(60 cases)and control group(60 cases)by random number table method. All cases were treated with aerosol inhalation of oxygen based on the anti - infective,anti - bronchospasm and fever- reducing drugs,cases in treatment group and in control group were given aerosol inhalation of N - acetylcysteine and ambroxol hydrochloride,respectively. The main symptoms and signs( body temperature,shortness of breath,cough and pulmonary rales ), adverse reactions, disappearance time of symptoms and signs, and hospitalization days were observed and recorded. Results The total effective rate was 95. 0% (57 / 60)in treatment group and 83. 3% (50 / 60)in control group,the difference was statistically significant( χ2 = 4. 227,P ﹤ 0. 05). There were significant differences in disappearance time of symptoms and signs(body temperature,shortness of breath,cough and pulmonary rales)and hospitalization days between the two groups(P ﹤ 0. 05). Incidence of adverse reactions was 1. 7% (1 / 60)in treatment group and 5. 3% (3 / 60)in control group,the difference was not statistically significant(χ2 = 1. 034,P ﹤ 0. 05). Conclusion Treating bronchopneumonia with aerosol inhalation of N - acetylcysteine and oxygen among infants can shorten the course of disease and improve cure rate,it has no significant adverse reaction,and is worthy of being widely applied in clinic.