CAJ | 학술논문

目的：探讨影响妊娠合并系统性红斑狼疮（SLE）妊娠结局的相关因素，提出SLE患者最佳受孕时机和孕期的治疗监护，预防妊娠合并SLE的恶化及SLE对妊娠的不良影响，以提高围产质量。方法回顾性分析25例妊娠合并SLE的临床资料。结果25例妊娠合并SLE患者，14例病情处于缓解期或控制期的患者，仅1例双胎妊娠发生早产，新生儿窒息0例，1例孕妇狼疮性肾炎加重，子痫前期0例；11例病情未控制或有SLE活动者，发生早产4例，新生儿窒息2例，孕期发生狼疮性肾炎3例，血小板减少3例，子痫前期2例。结论SLE患者应首先控制疾病的活动，在产科医师及风湿免疫科医师的指导下受孕，妊娠期加强胎儿监护及SLE疾病的监测、治疗。泼尼松是目前安全可靠的妊娠期治疗及预防SLE恶化、控制SLE活动的首选药物。SLE孕妇应加强孕期的监护，争取良好的妊娠结局。
목적：탐토영향임신합병계통성홍반랑창（SLE）임신결국적상관인소，제출SLE환자최가수잉시궤화잉기적치료감호，예방임신합병SLE적악화급SLE대임신적불량영향，이제고위산질량。방법회고성분석25례임신합병SLE적림상자료。결과25례임신합병SLE환자，14례병정처우완해기혹공제기적환자，부1례쌍태임신발생조산，신생인질식0례，1례잉부랑창성신염가중，자간전기0례；11례병정미공제혹유SLE활동자，발생조산4례，신생인질식2례，잉기발생랑창성신염3례，혈소판감소3례，자간전기2례。결론SLE환자응수선공제질병적활동，재산과의사급풍습면역과의사적지도하수잉，임신기가강태인감호급SLE질병적감측、치료。발니송시목전안전가고적임신기치료급예방SLE악화、공제SLE활동적수선약물。SLE잉부응가강잉기적감호，쟁취량호적임신결국。
Objective To investigate the correlative factors that affect the outcome of pregnancy complicated with SLE and try to provide the best chance for conception and pregnant monitoring, to prevent the deterioration of SLE and improve the perinatal quality. Methods Retrospective analysis of 25 cases of pregnancy complicated with SLE. Results In 25 cases pregnancy complicated with SLE, 14 cases were in remission and well-controlled stage, 1 case premature labor, neonatal asphyxia 0 case, lupus nephritis 1 case, preeclampsia 0 case, 11 cases unstable, premature labor 4 cases, neonatal asphyxia 2 cases, lupus nephritis 3 cases, low serum platelet 3 cases, preeclampsia 2 cases. Conclusion The results show that first of all, the activity of SLE should be controlled and patients should get conception under the guidance of the obstetricians and physicians, Prednisone is one of the safe drugs for prevent women to control the activation of SLE and to prevent deterioration. Intensive monitors should be offered to prevent women complicated with SLE to acquire a better pregnancy outcome.