中国血液流变学杂志
中國血液流變學雜誌
중국혈액류변학잡지
CHINESE JOURNAL OF HEMORHEOLOGY
2014年
2期
290-291,310
,共3页
李燕林%王永清%朱迪卿%周益平
李燕林%王永清%硃迪卿%週益平
리연림%왕영청%주적경%주익평
过敏性紫癜%细胞免疫%T细胞亚群
過敏性紫癜%細胞免疫%T細胞亞群
과민성자전%세포면역%T세포아군
Henoch-Schonlein purpura%cellular immunity%T lymphocyte subset
目的:探讨过敏性紫癜(HSP)患儿急性期外周血淋巴细胞免疫功能变化及其临床意义。方法采用流式细胞术法分别测定32例HSP患儿急性期外周血T细胞亚群CD3+T细胞、CD4+T细胞、CD8+T细胞、CD4+/CD8+的水平,并与20名健康儿童比较分析。结果HSP患儿急性期外周血T细胞亚群CD4+T细胞和CD4+/CD8+均降低,而CD8+T细胞水平增高,与对照组比较差异有统计学意义(P<0.05);CD3+T细胞差异无统计学意义(P>0.05)。结论 HSP急性期存在细胞免疫功能紊乱,并且其可能为HSP的发病机制。
目的:探討過敏性紫癜(HSP)患兒急性期外週血淋巴細胞免疫功能變化及其臨床意義。方法採用流式細胞術法分彆測定32例HSP患兒急性期外週血T細胞亞群CD3+T細胞、CD4+T細胞、CD8+T細胞、CD4+/CD8+的水平,併與20名健康兒童比較分析。結果HSP患兒急性期外週血T細胞亞群CD4+T細胞和CD4+/CD8+均降低,而CD8+T細胞水平增高,與對照組比較差異有統計學意義(P<0.05);CD3+T細胞差異無統計學意義(P>0.05)。結論 HSP急性期存在細胞免疫功能紊亂,併且其可能為HSP的髮病機製。
목적:탐토과민성자전(HSP)환인급성기외주혈림파세포면역공능변화급기림상의의。방법채용류식세포술법분별측정32례HSP환인급성기외주혈T세포아군CD3+T세포、CD4+T세포、CD8+T세포、CD4+/CD8+적수평,병여20명건강인동비교분석。결과HSP환인급성기외주혈T세포아군CD4+T세포화CD4+/CD8+균강저,이CD8+T세포수평증고,여대조조비교차이유통계학의의(P<0.05);CD3+T세포차이무통계학의의(P>0.05)。결론 HSP급성기존재세포면역공능문란,병차기가능위HSP적발병궤제。
Objective To investigate the changes and clinical significance of peripheral lymphocyte immune function in Henoch-Schonlein purpura (HSP) children of acute phase. Methods The levels of peripheral CD3+T cells, CD4+T cells, CD8+T cells, CD4+/CD8+in HSP children of acute phase (n=32) and healthy controls (n=20) were detected by flow cytometry. Results The levels of CD4+T cells and CD4+/CD8+in HSP children of acute phase were significantly lower than those of controls (P<0.05), while the level of CD8+T cells was significantly higher than those of controls (P<0.05). There is no significant difference in CD3+T cells between HSP group and control group (P>0.05). Conclusion The HSP children of acute phase display the T-cell dysfunction, and it may involve in the pathogenesis of HSP.