CAJ | 학술논문

目的：探讨平均血小板体积（mean platelet volume, MPV）作为胃癌早期诊断指标的应用价值。方法回顾52例胃癌根治术患者术前，及术后2周的血常规检测结果，同时招募52名年龄、性别相匹配的健康志愿者作为对照纳入研究。分析胃癌患者MPV水平与临床病理特征的相关性；胃癌患者术前及术后MPV水平的差异；以及胃癌患者术前、术后的MPV水平与健康志愿者的差异。结果胃癌患者MPV水平与性别、年龄、肿瘤大小、淋巴结转移、肿瘤分级均无明显相关性（P＞0.05）；胃癌患者术前MPV水平与对照组差异有统计学意义（8.41±0.58 fL vs.7.68±0.56 fL，P＜0.001）；胃癌患者术前与术后的MPV水平差异有统计学意义（8.41±0.58 fL vs.7.65±0.53 fL，P＜0.001）；胃癌患者术后MPV水平与对照组差异无统计学意义（7.65±0.53 fL vs.7.68±0.56 fL，P=0.720）。结论 MPV有可能应用于胃癌高危人群的早期诊断。
목적：탐토평균혈소판체적（mean platelet volume, MPV）작위위암조기진단지표적응용개치。방법회고52례위암근치술환자술전，급술후2주적혈상규검측결과，동시초모52명년령、성별상필배적건강지원자작위대조납입연구。분석위암환자MPV수평여림상병리특정적상관성；위암환자술전급술후MPV수평적차이；이급위암환자술전、술후적MPV수평여건강지원자적차이。결과위암환자MPV수평여성별、년령、종류대소、림파결전이、종류분급균무명현상관성（P＞0.05）；위암환자술전MPV수평여대조조차이유통계학의의（8.41±0.58 fL vs.7.68±0.56 fL，P＜0.001）；위암환자술전여술후적MPV수평차이유통계학의의（8.41±0.58 fL vs.7.65±0.53 fL，P＜0.001）；위암환자술후MPV수평여대조조차이무통계학의의（7.65±0.53 fL vs.7.68±0.56 fL，P=0.720）。결론 MPV유가능응용우위암고위인군적조기진단。
Objective To investigate the application of mean platelet volume (MPV) in the early diagnosis of gastric cancer. Methods 52 gastric cancer patients and 52 age-sexes matched healthy subjects were enrolled in this study. MPV level of gastric cancer patient was tested pre-operation and 2 weeks after operation. MPV levels were compared between pre-and post-operative samples. The pre-and post-operative MPV levels were also compared with the MPV level obtained from healthy subjects respectively. Results MPV level was significantly higher in pre-operative gastric cancer patients compared to healthy subjects (8.41±0.58 fL vs. 7.68±0.56 fL, P<0.001). The MPV level decreased significantly 2 weeks after operation (8.41±0.58 fL vs. 7.65±0.53 fL, P<0.001). There was no significant difference in MPV levels of post-operative patients and healthy subjects (7.65±0.53 fL vs. 7.68±0.56 fL, P=0.720). Conclusion Changes in MPV values may be used as an easily available biomarker for monitoring the healthy patients bearing gastric cancer risks and may contribute to the early diagnosis of gastric cancer.