CAJ | 학술논문

目的：观察血糖控制水平与慢性心力衰竭合并糖尿病患者预后的关系。方法：选择228例慢性心力衰竭伴糖尿病的患者，根据随访过程中患者糖化血红蛋白（HbA1c）水平分为血糖控制达标组（HbA1c ＜7．0％）与血糖控制不佳组（HbA1c ≥7．0％），比较随访期间两组联合主要心血管事件发生率及无联合主要心血管事件生存率的的差异。结果：随访期间两组患者左室射血分数（LVEF）及 N-末端 B 型利钠肽原（NT-proBNP）水平无统计学差异；与血糖控制不佳组相比，血糖控制达标组的联合主要心血管事件发生率较低（P ＝0．039），无联合主要心血管事件生存率较高（P ＜0．05）。结论：控制血糖使 HbA1c＜7．0％有利于改善慢性心力衰竭合并糖尿病患者的预后。
목적：관찰혈당공제수평여만성심력쇠갈합병당뇨병환자예후적관계。방법：선택228례만성심력쇠갈반당뇨병적환자，근거수방과정중환자당화혈홍단백（HbA1c）수평분위혈당공제체표조（HbA1c ＜7．0％）여혈당공제불가조（HbA1c ≥7．0％），비교수방기간량조연합주요심혈관사건발생솔급무연합주요심혈관사건생존솔적적차이。결과：수방기간량조환자좌실사혈분수（LVEF）급 N-말단 B 형리납태원（NT-proBNP）수평무통계학차이；여혈당공제불가조상비，혈당공제체표조적연합주요심혈관사건발생솔교저（P ＝0．039），무연합주요심혈관사건생존솔교고（P ＜0．05）。결론：공제혈당사 HbA1c＜7．0％유리우개선만성심력쇠갈합병당뇨병환자적예후。
Objective:To explore the relationship between blood glucose levels and prognosis in patients with chronic heart failure (CHF)and diabetes mellitus (DM). Methods:A cohort of 228 patients diagnosed as CHF complicated by DM were enrolled in this study. According to blood glycosylated hemoglobin A1c (HbA1c)levels,patients were divided into two groups:standard group (HbA1c < 7.0%) and unstandard group (HbA1c ≥ 7.0%). The incidence of composite major cardiovascular events (MCE)and MCE-free mortality were recorded during follow-up. Results:There was no significant difference in levels of N-terminal pro-brain natriuretic peptide (NT-proBNP)and left ventricular ejection fraction between the two groups.Compared with unstandard group,incidence of MCE was significantly reduced,and MCE-free mortality was increased in standard group (P <0.05). Conclusion:Glycemic control for achieving HbA1c levels of less than 7.0% is beneficial to improve the prognosis of CHF patients with DM.