CAJ | 학술논문

目的：评价氨磷汀对胃肠道肿瘤化疗药物奥沙利铂所致神经毒性的改善作用。方法将行FOLF-OX6方案化疗的86例胃肠道肿瘤患者随机分为氨磷汀组（给予奥沙利铂前静脉注射氨磷汀，n＝43）和对照组（不予氨磷汀，n＝43）。每2个周期评估神经毒性。结果经过8个周期化疗后，氨磷汀组患者3～4级神经毒性发生率（4.9%）较对照组（16.3%）有明显降低，组间差异具有统计学意义（P＜0.001）。氨磷汀组患者化疗后正中神经和腓神经的感觉神经传导速度分别为（53.75±2.96）m/s和（54.94±2.98）m/s，均明显优于对照组的（45.16±3.13）m/s和（5.05±3.02）m/s，组间差异具有统计学意义（P＜0.001）。化疗近期有效率两组间无显著差异（P＝0.451）。结论氨磷汀对奥沙利铂化疗所致神经毒性具有明显改善作用，且不影响化疗的近期疗效。
목적：평개안린정대위장도종류화료약물오사리박소치신경독성적개선작용。방법장행FOLF-OX6방안화료적86례위장도종류환자수궤분위안린정조（급여오사리박전정맥주사안린정，n＝43）화대조조（불여안린정，n＝43）。매2개주기평고신경독성。결과경과8개주기화료후，안린정조환자3～4급신경독성발생솔（4.9%）교대조조（16.3%）유명현강저，조간차이구유통계학의의（P＜0.001）。안린정조환자화료후정중신경화비신경적감각신경전도속도분별위（53.75±2.96）m/s화（54.94±2.98）m/s，균명현우우대조조적（45.16±3.13）m/s화（5.05±3.02）m/s，조간차이구유통계학의의（P＜0.001）。화료근기유효솔량조간무현저차이（P＝0.451）。결론안린정대오사리박화료소치신경독성구유명현개선작용，차불영향화료적근기료효。
Objective To explore the effect of amifostine in improving neurotoxicity induced by oxaliplatin on gastroenteric tumor patients. Method A total of 86 patients with gastroenteric tumor were enrolled and randomized into treatment group (combined with intravenous amifostine 500 mg/m2 before oxaliplatin, 43 cases) and control group (43 cases). All patients received FOLFOX6 regimen. Neurological toxicities were assessed every 2 cycles. Re-sult The occurrence rates of grade 3-4 peripheral neurotoxicity after 8 cycles of chemotherapy were significantly lower in treatment group than in control group (4.9% vs 16.3%, P<0.001). The sensory nerve conduction velocity (SCV) was significantly improved in treatment group [SCVmedian nerve = (53.75 ± 2.96) m/s, SCVperoneal nerve = (54.94 ± 2.98) m/s] than in control group [SCVmedian nerve = (45.16 ± 3.13 m/s, SCVperoneal nerve = (5.05 ± 3.02 m/s] (P<0.001). The short-time efficacy of chemotherapy were similar in two groups (P=0.451). Conclusion Amifostine can im-prove the neurotoxicity induced by oxaliplatine, but do not affect response to chemotherapy.