CAJ | 학술논문

目的：探讨阿瑞匹坦联合盐酸格拉司琼注射液和地塞米松预防乳腺癌FAC方案化疗致恶心、呕吐的治疗效果。方法收集中国医科大学附属盛京医院2014年1月—2014年6月行FAC方案化疗乳腺癌患者76例，按照入院先后顺序采用随机分组分为观察组（阿瑞匹坦+盐酸格拉司琼注射液+地塞米松）及对照组（盐酸格拉司琼注射液+地塞米松），每组各38例，比较2组对预防化疗所致恶心、呕吐的临床疗效，不良反应及对生活质量的影响。结果观察组恶心控制率为84?.2％，优于对照组的65.7％（χ2=4.324， P ＜0.05）；观察组急性呕吐有效率为81.6％，优于对照组的63.2％（χ2=4.213， P ＜0.05）；观察组延迟性呕吐有效率为79.0％，优于对照组的60.6％（χ2=3.172， P ＜0.05）。不良反应方面，2组比较无显著性差异（ P ＞0.05）；生存质量评价，观察组明显高于对照组，2组比较差异有统计学意义（ P ＜0.05）。结论阿瑞匹坦联合盐酸格拉司琼注射液、地塞米松能够有效预防乳腺癌FAC方案化疗所致恶心呕吐，不良反应轻，提高患者生存质量，值得推广。
목적：탐토아서필탄연합염산격랍사경주사액화지새미송예방유선암FAC방안화료치악심、구토적치료효과。방법수집중국의과대학부속성경의원2014년1월—2014년6월행FAC방안화료유선암환자76례，안조입원선후순서채용수궤분조분위관찰조（아서필탄+염산격랍사경주사액+지새미송）급대조조（염산격랍사경주사액+지새미송），매조각38례，비교2조대예방화료소치악심、구토적림상료효，불량반응급대생활질량적영향。결과관찰조악심공제솔위84?.2％，우우대조조적65.7％（χ2=4.324， P ＜0.05）；관찰조급성구토유효솔위81.6％，우우대조조적63.2％（χ2=4.213， P ＜0.05）；관찰조연지성구토유효솔위79.0％，우우대조조적60.6％（χ2=3.172， P ＜0.05）。불량반응방면，2조비교무현저성차이（ P ＞0.05）；생존질량평개，관찰조명현고우대조조，2조비교차이유통계학의의（ P ＜0.05）。결론아서필탄연합염산격랍사경주사액、지새미송능구유효예방유선암FAC방안화료소치악심구토，불량반응경，제고환자생존질량，치득추엄。
Objective To investigate the effect of aprepitant combined granisetron hydrochloride injection and dexam -ethasone in the prevention of nausea , vomiting induced by FAC regimen chemotherapy of breast cancer .Methods From 2014 January to 2014 June, collected 76 cases of breast cancer patients who were received chemotherapy of FAC regimen in Shengjing Hospital Affiliated to China Medical University , in accordance with the order of admission , they were randomly di-vided into observation group ( aprepitant +granisetron hydrochloride injection +dexamethasone ) and control group ( granise-tron hydrochloride injection +dexamethasone), each group of 38 cases, compared the 2 groups'clinical efficacy of prevention of nausea , vomiting induced by chemotherapy , adverse reactions and the quality of life .Results The observation group nau-sea control rate was 84.2%,which was better than the control group of 65.7%(χ2 =4.324, P <0.05);observation group's acute vomiting efficiency was 81.6%, which was better than the control group of 63.2%(χ2 =4.213, P <0.05);the effec-tive rate of delayed vomiting in the observation group was 79.0%, which was better than the control group of 60.6% (χ2 =3.172, P <0.05).Adverse reactions revealed no significant differences between the 2 groups ( P >0.05);evaluation of the quality of life , the observation group was significantly higher than that in the control group , there was significant difference be-tween the 2 groups ( P <0.05).Conclusion Aprepitant combined granisetron hydrochloride injection and dexamethasone can effectively prevent nausea and vomiting caused by FAC chemotherapy in breast cancer patients with mild adverse reac -tions, it can improve the quality of life of patients and worthy of promotion .