CAJ | 학술논문

目的：检测类风湿性关节炎（RA）患者血清铁调素（Hepc）水平的变化，并探讨其临床意义。方法2012年8月—2014年2月接受治疗的RA患者72例作为病例组，选取正常体检人群54例作为健康对照组。以Hepc的血清水平（5?.86 ng／ml）为界限将RA组分为正常亚组和升高亚组。比较2组受试者的炎性因子、血红蛋白（ Hb）、Hepc水平和疾病活动性评分（DAS28），并探讨RA患者血清Hepc水平与患者临床指标间的相关性。结果 RA组患者的CRP、TNF-α、IL-6、Hb和Hepc的水平均显著高于健康对照组，差异具有统计学意义（ t =6.445、3.293、3.910、2.874，8.572， P均＜0.01）；Hepc正常亚组患者的DAS28评分、IL-6水平均显著低于Hepc升高亚组（ t =3.142、4.420， P均＜0.01）；RA组患者的Hepc水平与DAS28、类风湿因子（ RF）、IL-6水平呈线性正相关关系（ r =0.288， P ＜0.01；r =0.271， P =0.01；r =0.301， P =0.02）。结论 Hepc与RA患者的机体炎性状况、疾病活动程度有着明显的相关性。
목적：검측류풍습성관절염（RA）환자혈청철조소（Hepc）수평적변화，병탐토기림상의의。방법2012년8월—2014년2월접수치료적RA환자72례작위병례조，선취정상체검인군54례작위건강대조조。이Hepc적혈청수평（5?.86 ng／ml）위계한장RA조분위정상아조화승고아조。비교2조수시자적염성인자、혈홍단백（ Hb）、Hepc수평화질병활동성평분（DAS28），병탐토RA환자혈청Hepc수평여환자림상지표간적상관성。결과 RA조환자적CRP、TNF-α、IL-6、Hb화Hepc적수평균현저고우건강대조조，차이구유통계학의의（ t =6.445、3.293、3.910、2.874，8.572， P균＜0.01）；Hepc정상아조환자적DAS28평분、IL-6수평균현저저우Hepc승고아조（ t =3.142、4.420， P균＜0.01）；RA조환자적Hepc수평여DAS28、류풍습인자（ RF）、IL-6수평정선성정상관관계（ r =0.288， P ＜0.01；r =0.271， P =0.01；r =0.301， P =0.02）。결론 Hepc여RA환자적궤체염성상황、질병활동정도유착명현적상관성。
Objective To detect the changes of the levels of rheumatoid arthritis ( RA) patients serum hepcidin (Hepc), and to explore its clinical significance .Methods From 2012 August to 2014 February, 72 patients with RA were selected as RA group , 54 cases with normal physical examination were enrolled as healthy control group .With the serum level of Hepc (5.86 ng/ml) as the limit of RA, they were divided into normal subgroups and the elevation subgroup .Inflammatory factor, hemoglobin (Hb),the level of Hepc and disease activity score 28(DAS28) were compared between the 2 groups of subjects, and to explore the correlation between clinical indexes and serum Hepc level in patients with RA .Results RA group's CRP, TNF alpha, IL-6, Hb and Hepc levels were significantly higher than that in healthy control group with statistical -ly significant difference ( t =6.445,3.293, 3.910,2.874,8.572, P <0.01);Hepc normal subgroup 's DAS28 scores, IL-6 levels were significantly lower than the Hepc elevation subgroup ( t =3.142,4.420, P <0.01); Hepc levels of patients in the RA group were positive correlated with disease activity score (DAS28) and rheumatoid factor (RF), IL-6 level ( r =0. 288, P <0.01;r =0.271, P =0.01;r =0.301, P =0.02).Conclusion The level of Hepc has closely relationship to in-flammatory status and disease activity in RA patients .