CAJ | 학술논문

目的：探讨巨噬细胞移动抑制因子（ MIF）与2型糖尿病（ DM）并发大血管病的关系。方法2型DM患者126例按是否发生大血管病变分为A组（ n =65，发生血管病变者）和B组（ n =61，未发生血管病变者），同期入选体检正常者60例为作为健康对照组（ C组）。采用高分辨超声检测186例入选者的颈动脉内膜中层厚度（ IMT ），并进行MIF、空腹血糖（FPG）、糖化血红蛋白（HbAlc）、低密度脂蛋白（LDL-C）、高密度脂蛋白（HDL-C）、三酰甘油（TG）的实验室检查。结果 A、B 2组的各项监测结果（除HDL-C）均高于C组；A组的MIF、IMT、HbAlc、LDL-C、TG水平均高于B组，HDL-C低于B组，且差异有统计学意义（ P ＜0 k.05， P ＜0.01）；A组颈动脉轻度狭窄22例（33.85％），中度32例（49.23％），重度11例（16.92％）；患者MIF水平与IMT（ r =0.977）、FPG（ r =0.551）、HbAlc（ r =0.909）、LDL-C （r =0.779）、TG（ r =0.615）呈正相关性（均P ＜0.01），与HDL-C水平呈负相关（ r =-0.516， P ＜0.01）。结论2型DM患者血浆MIF水平明显升高；发生血管病变的2型DM患者MIF水平与血管病变程度关系密切，且与血糖、血脂相关；2型DM患者进行MIF水平监测对防控大血管病变具有较高价值。
목적：탐토거서세포이동억제인자（ MIF）여2형당뇨병（ DM）병발대혈관병적관계。방법2형DM환자126례안시부발생대혈관병변분위A조（ n =65，발생혈관병변자）화B조（ n =61，미발생혈관병변자），동기입선체검정상자60례위작위건강대조조（ C조）。채용고분변초성검측186례입선자적경동맥내막중층후도（ IMT ），병진행MIF、공복혈당（FPG）、당화혈홍단백（HbAlc）、저밀도지단백（LDL-C）、고밀도지단백（HDL-C）、삼선감유（TG）적실험실검사。결과 A、B 2조적각항감측결과（제HDL-C）균고우C조；A조적MIF、IMT、HbAlc、LDL-C、TG수평균고우B조，HDL-C저우B조，차차이유통계학의의（ P ＜0 k.05， P ＜0.01）；A조경동맥경도협착22례（33.85％），중도32례（49.23％），중도11례（16.92％）；환자MIF수평여IMT（ r =0.977）、FPG（ r =0.551）、HbAlc（ r =0.909）、LDL-C （r =0.779）、TG（ r =0.615）정정상관성（균P ＜0.01），여HDL-C수평정부상관（ r =-0.516， P ＜0.01）。결론2형DM환자혈장MIF수평명현승고；발생혈관병변적2형DM환자MIF수평여혈관병변정도관계밀절，차여혈당、혈지상관；2형DM환자진행MIF수평감측대방공대혈관병변구유교고개치。
Objective To investigate the relationship between the expression of macrophage migration inhibitory fac -tor ( MIF) and type 2 diabetes mellitus ( DM) complicated with macrovascular disease .Methods According to with or with-out occurrence of major vascular lesions , type 2 DM patients (126 cases) were divided into group A ( n =65, vascular le-sions) and group B ( n =61, there was no vascular lesions ), 60 healthy subjects over the same period were selected as the healthy control group ( group C ) .Using the high-resolution ultrasound to detect the carotid artery intima-media thickness (IMT), MIF, fasting blood glucose (FPG), glycosylated hemoglobin (HbA1c), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglycerol (TG) were detected by laboratory examination in these 186 ca-ses of the participants .Results Group A and B 's monitoring results ( except HDL-C) were higher than those in group C;group A's MIF, IMT, HbA1c, LDL-C and TG levels were higher than in the group B , HDL-C were lower than in group B, and the difference had statistical significance ( P <0.05, P <0.01); carotid artery mild stenosis were 22 cases in group A (33.85%), moderate of 32 cases (49.23%), 11 cases of severe (16.92%);the level of MIF was positively correlated with IMT ( r =0.977), FPG ( r =0.551), HbA1c( r =0.909), LDL C ( r =0.779), TG ( r =0.615) (all P <0.01), and negatively correlated with HDL-C levels ( r =-0.516, P <0.01).Conclusion The MIF level in type 2 DM patients in-creased significantly;type 2 DM patients with vascular lesions , their MIF level was closely related of the degree of vascular le-sions, and correlated with blood glucose and blood lipid;monitoring the level of MIF in patients with type 2 DM has a higher value for the prevention and control of large vascular disease .