中国社区医师
中國社區醫師
중국사구의사
Chinese Community Doctors
2014年
36期
150-151
,共2页
中枢神经系统肿瘤%弥漫大B细胞淋巴瘤%临床病理特征
中樞神經繫統腫瘤%瀰漫大B細胞淋巴瘤%臨床病理特徵
중추신경계통종류%미만대B세포림파류%림상병리특정
Central nervous system%Diffuse large B cell lymphoma%Clinical pathological features
目的：探讨原发中枢神经系统弥漫大B细胞淋巴瘤临床病理特征、诊断与鉴别诊断。方法：回顾性分析12例原发中枢神经系统弥漫大B细胞淋巴瘤患者临床资料、组织学病理形态及免疫组化结果。结果：12例患者平均年龄53.2岁，光镜下可见肿瘤细胞呈弥漫浸润性分布，与脑组织无明显分界，某些区域肿瘤细胞聚集在血管周围，呈袖套样结构，浸润和破坏血管壁。免疫组化示12例CD20、CD79а、PAX5和BCL-6均弥漫阳性，Ki-67增殖指数40%～90%；CD3、CD10、Mum-1、GFAP、S-100和CKpn均阴性。结论：原发中枢神经系统弥漫大B细胞淋巴瘤发病率低，临床无特异性，恶性程度高，正确掌握临床病理与免疫组化特征对该病的诊断具有重要意义。
目的：探討原髮中樞神經繫統瀰漫大B細胞淋巴瘤臨床病理特徵、診斷與鑒彆診斷。方法：迴顧性分析12例原髮中樞神經繫統瀰漫大B細胞淋巴瘤患者臨床資料、組織學病理形態及免疫組化結果。結果：12例患者平均年齡53.2歲，光鏡下可見腫瘤細胞呈瀰漫浸潤性分佈，與腦組織無明顯分界，某些區域腫瘤細胞聚集在血管週圍，呈袖套樣結構，浸潤和破壞血管壁。免疫組化示12例CD20、CD79а、PAX5和BCL-6均瀰漫暘性，Ki-67增殖指數40%～90%；CD3、CD10、Mum-1、GFAP、S-100和CKpn均陰性。結論：原髮中樞神經繫統瀰漫大B細胞淋巴瘤髮病率低，臨床無特異性，噁性程度高，正確掌握臨床病理與免疫組化特徵對該病的診斷具有重要意義。
목적：탐토원발중추신경계통미만대B세포림파류림상병리특정、진단여감별진단。방법：회고성분석12례원발중추신경계통미만대B세포림파류환자림상자료、조직학병리형태급면역조화결과。결과：12례환자평균년령53.2세，광경하가견종류세포정미만침윤성분포，여뇌조직무명현분계，모사구역종류세포취집재혈관주위，정수투양결구，침윤화파배혈관벽。면역조화시12례CD20、CD79а、PAX5화BCL-6균미만양성，Ki-67증식지수40%～90%；CD3、CD10、Mum-1、GFAP、S-100화CKpn균음성。결론：원발중추신경계통미만대B세포림파류발병솔저，림상무특이성，악성정도고，정학장악림상병리여면역조화특정대해병적진단구유중요의의。
Objective:To explore the clinical pathological features,diagnosis and differential diagnosis of primary central nervous system diffuse large B cell lymphoma.Methods:The clinical data,histological pathological morphology and immunohistochemical results of 12 patients with primary central nervous system diffuse large B cell lymphoma were retrospectively analyzed.Results:The average age of 12 patients was 53.2 years.Visible tumor cells showed diffuse invasive distribution under light microscope, there was no boundaries with brain tissue,tumor cells in certain areas aggregated around vessel with raglan sleeves structure. There were infiltration and destruction of vascular wall.Immunohistochemistry showed that 12 cases of CD20,CD79,PAX5 and BCL-6 were positive,Ki-67 proliferation index was 40%~90%;CD3,CD10,Mum-1,GFAP,S-100 and CKpn were all negative. Conclusion:The incidence rate of primary central nervous system diffuse large B cell lymphoma is low.It has no clinical specificity. Its malignancy degree is high.Correctly grasping the clinical pathological and immunohistochemical features have important significance to the diagnosis of the disease.
