CAJ | 학술논문

采用己二异氰酸酯三聚体（ HT）、2，4-甲苯二异氰酸酯（ TDI）、聚乙二醇800为基本原料，以1，4-丁二醇、2，2-二甲基丙酸和乙二胺为亲水扩链剂，合成了水性聚氨酯（ WPU），以CaCO3作为致孔剂制备多孔WPU膜，并与硫酸化壳聚糖（ SCS）接枝，制得多孔WPU／SCS复合膜，探讨了致孔剂的用量对WPU／SCS复合膜孔隙率和吸水率的影响．利用红外光谱仪和光学显微镜对复合膜的结构和形态进行了表征，并通过复钙化时间和动态凝血时间对其血液相容性进行了表征．结果表明，致孔剂CaCO3使用量为12％时，孔隙率为68.3％，吸水率达112.5％，多孔WPU／SCS复合膜具有较好的血液相容性，是一种理想的生物医用材料．
채용기이이청산지삼취체（ HT）、2，4-갑분이이청산지（ TDI）、취을이순800위기본원료，이1，4-정이순、2，2-이갑기병산화을이알위친수확련제，합성료수성취안지（ WPU），이CaCO3작위치공제제비다공WPU막，병여류산화각취당（ SCS）접지，제득다공WPU／SCS복합막，탐토료치공제적용량대WPU／SCS복합막공극솔화흡수솔적영향．이용홍외광보의화광학현미경대복합막적결구화형태진행료표정，병통과복개화시간화동태응혈시간대기혈액상용성진행료표정．결과표명，치공제CaCO3사용량위12％시，공극솔위68.3％，흡수솔체112.5％，다공WPU／SCS복합막구유교호적혈액상용성，시일충이상적생물의용재료．
Waterborne polyurethane was synthesized by the reaction of HDI trimmers (HT),toluene diisocyanate (TDI) and polyethylene glycol(PEG800) as raw materials,1,4-butylene glycol(BDO),2,2-dimethylol propionic acid( DMPA) and ethylenediamine( EDA) as hydrophilic chain extender.CaCO3 was used as pore-foaming agent to prepare the WPU porous composite membrane.Then,the WPU/SCS porous composite membrane was generated by surface grafting of sulfated chitosan onto the WPU porous composite membrane.The effects of the contents of pore-foaming agent on the porosity and water absorption of WPU/SCS porous composite membrane have been studied. The structure of the composite membrane was studied by Fourier transformation infrared spectrometer( FTIR) ,and the morphologies of the composite membrane were characterized by optical polarization micrograph ( OPM ) .The recalification time test and dynamic blood-clotting test were used to characterize the blood compatibility of the com-posite membrane.The results showed that the porosity and water absorption of the composite membrane were 68.3%and 112.5%respectively when the content of CaCO3 was 12%,the composite membrane possesed excellent blood compatibility.It was expected to be an excellent biomedical material.