CAJ | 학술논문

目的：探讨血清降钙素原（PC T ）检测在感染性疾病诊断及治疗中的应用价值。方法对500例住院患者采用荧光免疫法检测患者血清PCT水平，检测结果分4个等级，正常值小于0．5 ng／mL ，超过0．5 ng／mL为阳性阈值，＞10．0 ng／m L考虑重度感染。结果在非细菌感染性疾病组中阳性率为11．3％、其浓度较低，以0．5～2．0 ng／mL为主；细菌性感染组阳性率为83．5％，其浓度较高，多超过2．0 ng／mL ，且升高的程度与感染严重度密切相关。非细菌感染性疾病组及细菌感染组血清PCT 水平差异有统计学意义（P＜0．01）。结论非细菌感染性疾病患者血清中PC T水平不升高或轻度升高，而细菌性感染患者血清中PC T水平则明显升高，且升高的程度与感染性疾病的严重度及预后密切相关。
목적：탐토혈청강개소원（PC T ）검측재감염성질병진단급치료중적응용개치。방법대500례주원환자채용형광면역법검측환자혈청PCT수평，검측결과분4개등급，정상치소우0．5 ng／mL ，초과0．5 ng／mL위양성역치，＞10．0 ng／m L고필중도감염。결과재비세균감염성질병조중양성솔위11．3％、기농도교저，이0．5～2．0 ng／mL위주；세균성감염조양성솔위83．5％，기농도교고，다초과2．0 ng／mL ，차승고적정도여감염엄중도밀절상관。비세균감염성질병조급세균감염조혈청PCT 수평차이유통계학의의（P＜0．01）。결론비세균감염성질병환자혈청중PC T수평불승고혹경도승고，이세균성감염환자혈청중PC T수평칙명현승고，차승고적정도여감염성질병적엄중도급예후밀절상관。
Objective To investigate the application value of serum procalcitonin (PCT ) detection in the diag‐nosis and treatment of infectious diseases .Methods The PCT level in 500 inpatients was detected by using the fluo‐rescence immunoassay .The detection results were divided into 4 grades ,normal value <0 .5 ng/mL ,positive thresh‐old more than 0 .5 ng/mL ,severe infection >10 .0 ng/mL .Results The positive rate in the non‐bacterial infectious diseases group was 11 .3% ,the concentration was lower and mainly in the range of 0 .5 -2 .0 ng/mL ;which in the bacterial infection group was 83 .5% ,the concentration was higher and exceeded 2 ng/mL ,moreover the rising degree was closely related with infection severity .Serum PCT level had statistical difference between the non‐bacterial infec‐tious diseases group and the bacterial infection group (P<0 .01) .Conclusion Serum PCT level in the patients with non‐bacterial infectious diseases has no increase or slightly increase ,while which in the patients with bacterial infec‐tion is significantly increased and the increase degree is closely related with the severity and prognosis of infectious diseases .