CAJ | 학술논문

目的：探讨肺炎支原体肺炎患儿血清中白细胞介素4（IL‐4）、白细胞介素5（IL‐5）、白细胞介素13（IL‐13）水平及其与喘息发生的关系。方法收集2013年1～10月123例肺炎支原体肺炎患儿，根据临床表现分为喘息组53例和无喘息组70例，喘息组根据临床病情分为急性期喘息组23例和缓解期喘息组30例，同时收集同期50例无喘息健康儿童血清作对照，采用酶联免疫吸附试验（ELISA）测定血清中IL‐4、IL‐5、IL‐13水平。结果肺炎支原体肺炎患儿血清中IL‐4、IL‐5、IL‐13水平高于健康对照组，喘息组患儿血清中IL‐4、IL‐5、IL‐13水平高于无喘息组患儿，血清IL‐4、IL‐5、IL‐13在急性期喘息组、缓解期喘息组中水平差异具有统计学意义（P＜0．05）。患儿血清中IL‐4、IL‐5水平呈正相关（ r＝0．613，P＜0．05），其余指标无相关性。结论血清IL‐4、IL‐5、IL‐13在肺炎支原体肺炎伴喘息患儿中水平升高，且伴随着喘息症状的加重水平上升，对肺炎支原体肺炎的治疗有指导意义。
목적：탐토폐염지원체폐염환인혈청중백세포개소4（IL‐4）、백세포개소5（IL‐5）、백세포개소13（IL‐13）수평급기여천식발생적관계。방법수집2013년1～10월123례폐염지원체폐염환인，근거림상표현분위천식조53례화무천식조70례，천식조근거림상병정분위급성기천식조23례화완해기천식조30례，동시수집동기50례무천식건강인동혈청작대조，채용매련면역흡부시험（ELISA）측정혈청중IL‐4、IL‐5、IL‐13수평。결과폐염지원체폐염환인혈청중IL‐4、IL‐5、IL‐13수평고우건강대조조，천식조환인혈청중IL‐4、IL‐5、IL‐13수평고우무천식조환인，혈청IL‐4、IL‐5、IL‐13재급성기천식조、완해기천식조중수평차이구유통계학의의（P＜0．05）。환인혈청중IL‐4、IL‐5수평정정상관（ r＝0．613，P＜0．05），기여지표무상관성。결론혈청IL‐4、IL‐5、IL‐13재폐염지원체폐염반천식환인중수평승고，차반수착천식증상적가중수평상승，대폐염지원체폐염적치료유지도의의。
Objective To investigate the relationship between serum interleukin‐4(IL‐4) ,interleukin‐5(IL‐5) and interleukin‐13(IL‐13) with complicating wheezing occurrence in children patients with Mycoplasma pneumoniae pneumonia .Methods 123 children cases of Mycoplasma pneumoniae pneumonia in our hospital from January 2013 to October 2013 were collected and divided into the wheezing group (53 cases)and the non‐wheezing group(70 cases) ac‐cording to the clinical manifestations .The wheezing group were re‐divided into the acute stage group(23 cases) and the remission stage group(30 cases) according to the clinical condition .Contemporaneous 50 healthy children without wheezing were collected as the control group .The serum IL‐4 ,IL‐5 and IL‐13 levels were measured by ELISA .Re‐sults The serum levels of IL‐4 ,IL‐5 and IL‐13 in the Mycoplasma pneumoniae pneumonia were higher than those in the control group ,which in the wheezing group were higher than those in the non‐wheezing group .The levels of IL‐4 , IL‐5 and IL‐13 had statistical differences between the acute stage wheezing group and the remission stage wheezing group(P<0 .05) .There was a positively correlation between serum IL‐4 and IL‐5(r=0 .613 ,P<0 .05) ,and the oth‐er indexes had no correlation .Conclusion The serum levels of IL‐4 ,IL‐5 and IL‐13 are increased in children patients with Mycoplasma pneumoniae pneumonia complicating wheezing and increased along with the wheezing symptoms aggravation ,which has the guidance significance for the treatment of Mycoplasma pneumoniae pneumonia .