检验医学与临床
檢驗醫學與臨床
검험의학여림상
JOURNAL OF LABORATORY MEDICINE AND CLINICAL SCIENCES
2015年
1期
28-30
,共3页
新生儿感染%降钙素原%ROC曲线
新生兒感染%降鈣素原%ROC麯線
신생인감염%강개소원%ROC곡선
neonatal infection%PCT%ROC curve
目的：探讨多个实验室指标对于新生儿感染的早期诊断价值。方法选取确诊感染入院的新生儿30例，检测其血降钙素原（PCT）、超敏C反应蛋白（hs‐CRP）、白细胞介素‐6（IL‐6）、白细胞介素‐8（IL‐8）、肿瘤坏死因子‐α（TNF‐α）和白细胞计数（WBC），并以未感染的新生儿作为对照组，比较两组受试者上述指标的水平，用 ROC曲线评价这些指标对于新生儿感染诊断的临床应用价值。结果新生儿感染组各参数均高于对照组，差异有统计学意义（P＜0．05）；由 ROC曲线可知，PCT和hs‐CRP敏感度和特异性达100．0％，TNF‐α敏感度为96．7％，特异性为99．3％；IL‐6和IL‐8敏感度均为93．3％，但特异性分别为73．3％和80．0％，WBC则为70．0％和80．0％。结论各参数均可以用于新生儿感染诊断，但灵敏度与特异性均较高的是PCT 和hs‐CRP ，其次为TNF‐α；IL‐6和IL‐8敏感性虽高，但其特异性不甚满意；WBC 诊断价值虽最小，但却是临床必不可少的常规观察指标。
目的：探討多箇實驗室指標對于新生兒感染的早期診斷價值。方法選取確診感染入院的新生兒30例，檢測其血降鈣素原（PCT）、超敏C反應蛋白（hs‐CRP）、白細胞介素‐6（IL‐6）、白細胞介素‐8（IL‐8）、腫瘤壞死因子‐α（TNF‐α）和白細胞計數（WBC），併以未感染的新生兒作為對照組，比較兩組受試者上述指標的水平，用 ROC麯線評價這些指標對于新生兒感染診斷的臨床應用價值。結果新生兒感染組各參數均高于對照組，差異有統計學意義（P＜0．05）；由 ROC麯線可知，PCT和hs‐CRP敏感度和特異性達100．0％，TNF‐α敏感度為96．7％，特異性為99．3％；IL‐6和IL‐8敏感度均為93．3％，但特異性分彆為73．3％和80．0％，WBC則為70．0％和80．0％。結論各參數均可以用于新生兒感染診斷，但靈敏度與特異性均較高的是PCT 和hs‐CRP ，其次為TNF‐α；IL‐6和IL‐8敏感性雖高，但其特異性不甚滿意；WBC 診斷價值雖最小，但卻是臨床必不可少的常規觀察指標。
목적：탐토다개실험실지표대우신생인감염적조기진단개치。방법선취학진감염입원적신생인30례，검측기혈강개소원（PCT）、초민C반응단백（hs‐CRP）、백세포개소‐6（IL‐6）、백세포개소‐8（IL‐8）、종류배사인자‐α（TNF‐α）화백세포계수（WBC），병이미감염적신생인작위대조조，비교량조수시자상술지표적수평，용 ROC곡선평개저사지표대우신생인감염진단적림상응용개치。결과신생인감염조각삼수균고우대조조，차이유통계학의의（P＜0．05）；유 ROC곡선가지，PCT화hs‐CRP민감도화특이성체100．0％，TNF‐α민감도위96．7％，특이성위99．3％；IL‐6화IL‐8민감도균위93．3％，단특이성분별위73．3％화80．0％，WBC칙위70．0％화80．0％。결론각삼수균가이용우신생인감염진단，단령민도여특이성균교고적시PCT 화hs‐CRP ，기차위TNF‐α；IL‐6화IL‐8민감성수고，단기특이성불심만의；WBC 진단개치수최소，단각시림상필불가소적상규관찰지표。
Objective To investigate the early diagnosis value of multiple laboratory indicators for neonatal in‐fection .Methods 30 hospitalized neonates with infection were selected and 30 normal neonates were selected as the controls .The blood PCT ,hs‐CRP ,IL‐6 ,IL‐8 ,TNF‐α and WBC were detected .The levels of above indicators were compared between the two group .The clinical application value of these indicators for the diagnosis of neonatal infec‐tion was evaluated by using the ROC curves .Results The various parameters in the neonatal infection group were higher than those in the control group(P<0 .05);the ROC curves indicated that the sensitivity and specificity of PCT and hs‐CRP reached 100 .0% ,which of TNF‐αwere 96 .7% and 99 .3% respectively ;the sensitivity of IL‐8 and IL‐6 were 93 .3% and their specificity was 73 .3% and 80 .0% respectively ;the sensitivity and specificity of WBC were 70 .0% and 80 .0% respectively .Conclusion The above parameters can be used to diagnose neonatal infection ,PCT and hs‐CRP have the higher sensitivity and specificity ,followed by TNF‐α;although IL‐8 and IL‐6 have higher sensi‐tivity ,but their specificity is unsatisfactory ;WBC has the minimal diagnostic value ,but is an indispensable routine observation indicator in clinic .
